JN AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 89: 2707-2725, 2003. First published January 15, 2003; doi:10.1152/jn.00845.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
89/5/2707    most recent
00845.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (70)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Compte, A.
Right arrow Articles by Wang, X.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Compte, A.
Right arrow Articles by Wang, X.-J.

J Neurophysiol (May 1, 2003). 10.1152/jn.00845.2002
Submitted on Submitted 24 September 2002; accepted in final form 20 December 2002

Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model

Albert Compte,1,2 Maria V. Sanchez-Vives,2 David A. McCormick,3 and Xiao-Jing Wang1

 1Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454;  2Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior Investigaciones Científicas, 03550 San Juan de Alicante, Spain; and  3Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 96510

Compte, Albert, Maria V. Sanchez-Vives, David A. McCormick, and Xiao-Jing Wang. Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model. J. Neurophysiol. 89: 2707-2725, 2003. Slow oscillatory activity (<1 Hz) is observed in vivo in the cortex during slow-wave sleep or under anesthesia and in vitro when the bath solution is chosen to more closely mimic cerebrospinal fluid. Here we present a biophysical network model for the slow oscillations observed in vitro that reproduces the single neuron behaviors and collective network firing patterns in control as well as under pharmacological manipulations. The membrane potential of a neuron oscillates slowly (at <1 Hz) between a down state and an up state; the up state is maintained by strong recurrent excitation balanced by inhibition, and the transition to the down state is due to a slow adaptation current (Na+-dependent K+ current). Consistent with in vivo data, the input resistance of a model neuron, on average, is the largest at the end of the down state and the smallest during the initial phase of the up state. An activity wave is initiated by spontaneous spike discharges in a minority of neurons, and propagates across the network at a speed of 3-8 mm/s in control and 20-50 mm/s with inhibition block. Our work suggests that long-range excitatory patchy connections contribute significantly to this wave propagation. Finally, we show with this model that various known physiological effects of neuromodulation can switch the network to tonic firing, thus simulating a transition to the waking state.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. K. Esser, S. Hill, and G. Tononi
Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling
J Neurophysiol, October 1, 2009; 102(4): 2096 - 2111.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P.-O. Polack, S. Mahon, M. Chavez, and S. Charpier
Inactivation of the Somatosensory Cortex Prevents Paroxysmal Oscillations in Cortical and Related Thalamic Neurons in a Genetic Model of Absence Epilepsy
Cereb Cortex, September 1, 2009; 19(9): 2078 - 2091.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Fellin, M. M. Halassa, M. Terunuma, F. Succol, H. Takano, M. Frank, S. J. Moss, and P. G. Haydon
Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo
PNAS, September 1, 2009; 106(35): 15037 - 15042.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Curto, S. Sakata, S. Marguet, V. Itskov, and K. D. Harris
A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex
J. Neurosci., August 26, 2009; 29(34): 10600 - 10612.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. O. Mann, M. M. Kohl, and O. Paulsen
Distinct Roles of GABAA and GABAB Receptors in Balancing and Terminating Persistent Cortical Activity
J. Neurosci., June 10, 2009; 29(23): 7513 - 7518.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. S. Cash, E. Halgren, N. Dehghani, A. O. Rossetti, T. Thesen, C. Wang, O. Devinsky, R. Kuzniecky, W. Doyle, J. R. Madsen, et al.
The Human K-Complex Represents an Isolated Cortical Down-State
Science, May 22, 2009; 324(5930): 1084 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Gao, X. Meng, C. Ye, H. Zhang, C. Liu, Y. Dan, M.-m. Poo, J. He, and X. Zhang
Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli
J. Neurosci., May 6, 2009; 29(18): 6013 - 6021.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. V. Vyazovskiy, U. Faraguna, C. Cirelli, and G. Tononi
Triggering Slow Waves During NREM Sleep in the Rat by Intracortical Electrical Stimulation: Effects of Sleep/Wake History and Background Activity
J Neurophysiol, April 1, 2009; 101(4): 1921 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. D. Acker and S. D. Antic
Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites
J Neurophysiol, March 1, 2009; 101(3): 1524 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Murphy, B. A. Riedner, R. Huber, M. Massimini, F. Ferrarelli, and G. Tononi
Source modeling sleep slow waves
PNAS, February 3, 2009; 106(5): 1608 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Compte, R. Reig, V. F. Descalzo, M. A. Harvey, G. D. Puccini, and M. V. Sanchez-Vives
Spontaneous High-Frequency (10-80 Hz) Oscillations during Up States in the Cerebral Cortex In Vitro
J. Neurosci., December 17, 2008; 28(51): 13828 - 13844.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Englot, A. M. Mishra, P. K. Mansuripur, P. Herman, F. Hyder, and H. Blumenfeld
Remote Effects of Focal Hippocampal Seizures on the Rat Neocortex
J. Neurosci., September 3, 2008; 28(36): 9066 - 9081.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Kondgen, C. Geisler, S. Fusi, X.-J. Wang, H.-R. Luscher, and M. Giugliano
The Dynamical Response Properties of Neocortical Neurons to Temporally Modulated Noisy Inputs In Vitro
Cereb Cortex, September 1, 2008; 18(9): 2086 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Winograd, A. Destexhe, and M. V. Sanchez-Vives
Hyperpolarization-activated graded persistent activity in the prefrontal cortex
PNAS, May 20, 2008; 105(20): 7298 - 7303.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. V. Sanchez-Vives, V. F. Descalzo, R. Reig, N. A. Figueroa, A. Compte, and R. Gallego
Rhythmic Spontaneous Activity in the Piriform Cortex
Cereb Cortex, May 1, 2008; 18(5): 1179 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Hasenstaub, R. N. S. Sachdev, and D. A. McCormick
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
J. Neurosci., September 5, 2007; 27(36): 9607 - 9622.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. A. Johnson and D. V. Buonomano
Development and Plasticity of Spontaneous Activity and Up States in Cortical Organotypic Slices
J. Neurosci., May 30, 2007; 27(22): 5915 - 5925.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Massimini, F. Ferrarelli, S. K. Esser, B. A. Riedner, R. Huber, M. Murphy, M. J. Peterson, and G. Tononi
Triggering sleep slow waves by transcranial magnetic stimulation
PNAS, May 15, 2007; 104(20): 8496 - 8501.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Jacobi and E. Moses
Variability and Corresponding Amplitude-Velocity Relation of Activity Propagating in One-Dimensional Neural Cultures
J Neurophysiol, May 1, 2007; 97(5): 3597 - 3606.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Kepecs and S. Raghavachari
Gating Information by Two-State Membrane Potential Fluctuations
J Neurophysiol, April 1, 2007; 97(4): 3015 - 3023.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. Durstewitz and T. Gabriel
Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons
Cereb Cortex, April 1, 2007; 17(4): 894 - 908.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Haslinger, I. Ulbert, C. I. Moore, E. N. Brown, and A. Devor
Analysis of LFP Phase Predicts Sensory Response of Barrel Cortex
J Neurophysiol, September 1, 2006; 96(3): 1658 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Frohlich, M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability.
J. Neurosci., June 7, 2006; 26(23): 6153 - 6162.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Volgushev, S. Chauvette, M. Mukovski, and I. Timofeev
Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
J. Neurosci., May 24, 2006; 26(21): 5665 - 5672.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Fujisawa, N. Matsuki, and Y. Ikegaya
Single Neurons Can Induce Phase Transitions of Cortical Recurrent Networks with Multiple Internal States
Cereb Cortex, May 1, 2006; 16(5): 639 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Haider, A. Duque, A. R. Hasenstaub, and D. A. McCormick
Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition.
J. Neurosci., April 26, 2006; 26(17): 4535 - 4545.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. V. Rangan, D. Cai, and D. W. McLaughlin
Inaugural Article: Modeling the spatiotemporal cortical activity associated with the line-motion illusion in primary visual cortex
PNAS, December 27, 2005; 102(52): 18793 - 18800.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Geisler, N. Brunel, and X.-J. Wang
Contributions of Intrinsic Membrane Dynamics to Fast Network Oscillations With Irregular Neuronal Discharges
J Neurophysiol, December 1, 2005; 94(6): 4344 - 4361.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Cai, A. V. Rangan, and D. W. McLaughlin
Architectural and synaptic mechanisms underlying coherent spontaneous activity in V1
PNAS, April 19, 2005; 102(16): 5868 - 5873.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. A. Milojkovic, M. S. Radojicic, and S. D. Antic
A Strict Correlation between Dendritic and Somatic Plateau Depolarizations in the Rat Prefrontal Cortex Pyramidal Neurons
J. Neurosci., April 13, 2005; 25(15): 3940 - 3951.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. B. Patel, R. A. de Graaf, G. F. Mason, D. L. Rothman, R. G. Shulman, and K. L. Behar
The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
PNAS, April 12, 2005; 102(15): 5588 - 5593.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Hill and G. Tononi
Modeling Sleep and Wakefulness in the Thalamocortical System
J Neurophysiol, March 1, 2005; 93(3): 1671 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
F. P. Battaglia, G. R. Sutherland, and B. L. McNaughton
Hippocampal sharp wave bursts coincide with neocortical "up-state" transitions
Learn. Mem., November 1, 2004; 11(6): 697 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Massimini, R. Huber, F. Ferrarelli, S. Hill, and G. Tononi
The Sleep Slow Oscillation as a Traveling Wave
J. Neurosci., August 4, 2004; 24(31): 6862 - 6870.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Giugliano, P. Darbon, M. Arsiero, H.-R. Luscher, and J. Streit
Single-Neuron Discharge Properties and Network Activity in Dissociated Cultures of Neocortex
J Neurophysiol, August 1, 2004; 92(2): 977 - 996.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Potassium Model for Slow (2-3 Hz) In Vivo Neocortical Paroxysmal Oscillations
J Neurophysiol, August 1, 2004; 92(2): 1116 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. M. de la Prida and B. Gal
Synaptic Contributions to Focal and Widespread Spatiotemporal Dynamics in the Isolated Rat Subiculum In Vitro
J. Neurosci., June 16, 2004; 24(24): 5525 - 5536.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online