JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 89: 2874-2878, 2003; doi:10.1152/jn.00783.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, B.
Right arrow Articles by Gall, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, B.
Right arrow Articles by Gall, C. M.

J Neurophysiol (May 1, 2003). 10.1152/jn.00783.2002
Submitted on Submitted 10 September 2002; accepted in final form 9 January 2003

REPORT

Integrins Regulate NMDA Receptor-Mediated Synaptic Currents

Bin Lin,1 Amy C. Arai,2 Gary Lynch,1 and Christine M. Gall3

 1Department of Psychiatry and Human Behavior, University of California, Irvine, California 92612-1695;  2Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, Illinois 62702; and  3Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1275

Lin, Bin, Amy C. Arai, Gary Lynch, and Christine M. Gall. Integrins Regulate NMDA Receptor-Mediated Synaptic Currents. J. Neurophysiol. 89: 2874-2878, 2003. Synapses contain high concentrations of integrins, adhesion receptors known to influence the operation of neighboring transmembrane proteins. Evidence that integrins are important for consolidation of long-term potentiation suggests that these adhesion proteins may modulate activities of synaptic glutamate receptors. The present study provides a first test of the possibility that integrins modulate synaptic N-methyl-D-aspartate (NMDA)-type glutamate receptor activities. Excitatory postsynaptic currents (EPSCs) were recorded with whole cell clamp from hippocampal slices in which AMPA-type glutamate receptors and GABAA receptors were pharmacologically blocked. Microperfusion of the peptide integrin ligand gly-arg-gly-asp-ser-pro (GRGDSP) caused an approximately twofold increase in the amplitude and duration of NMDA receptor-gated synaptic currents. Control peptides had no effect. Paired-pulse facilitation was unchanged, indicating that the ligand did not modify neurotransmitter release probabilities. Infusion of the Src kinase antagonist PP2 but not the control drug 4-amino-7-phenylpyrazolo[3,4-d]pyrimidine eliminated the enhancing effect of GRGDSP. Integrins regulate Src kinases that are known to phosphorylate NMDA receptors. It is concluded that integrins act through this route to exert potent modulatory effects on the operation of NMDA receptors.




This article has been cited by other articles:


Home page
 J. Med. Genet.Home page
T V Bilousova, L Dansie, M Ngo, J Aye, J R Charles, D W Ethell, and I M Ethell
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
J. Med. Genet., February 1, 2009; 46(2): 94 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Zhang, L. Edelmann, J. Liu, J. E. Crandall, and M. A. Morabito
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
J. Neurosci., January 9, 2008; 28(2): 415 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Rohrbough, E. Rushton, E. Woodruff III, T. Fergestad, K. Vigneswaran, and K. Broadie
Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation
Genes & Dev., October 15, 2007; 21(20): 2607 - 2628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. K. Sfakianos, A. Eisman, S. L. Gourley, W. D. Bradley, A. J. Scheetz, J. Settleman, J. R. Taylor, C. A. Greer, A. Williamson, and A. J. Koleske
Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior
J. Neurosci., October 10, 2007; 27(41): 10982 - 10992.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. Bourgin, K. K. Murai, M. Richter, and E. B. Pasquale
The EphA4 receptor regulates dendritic spine remodeling by affecting {beta}1-integrin signaling pathways
J. Cell Biol., September 24, 2007; 178(7): 1295 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
O. Bozdagi, V. Nagy, K. T. Kwei, and G. W. Huntley
In Vivo Roles for Matrix Metalloproteinase-9 in Mature Hippocampal Synaptic Physiology and Plasticity
J Neurophysiol, July 1, 2007; 98(1): 334 - 344.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Wang, S. Carnicella, K. Phamluong, J. Jeanblanc, J. A. Ronesi, N. Chaudhri, P. H. Janak, D. M. Lovinger, and D. Ron
Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior
J. Neurosci., March 28, 2007; 27(13): 3593 - 3602.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Huang, K. Shimazu, N. H. Woo, K. Zang, U. Muller, B. Lu, and L. F. Reichardt
Distinct Roles of the beta1-Class Integrins at the Developing and the Mature Hippocampal Excitatory Synapse
J. Neurosci., October 25, 2006; 26(43): 11208 - 11219.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Gui, X. Wu, S. Ling, S. C. Stotz, R. J. Winkfein, E. Wilson, G. E. Davis, A. P. Braun, G. W. Zamponi, and M. J. Davis
Integrin Receptor Activation Triggers Converging Regulation of Cav1.2 Calcium Channels by c-Src and Protein Kinase A Pathways
J. Biol. Chem., May 19, 2006; 281(20): 14015 - 14025.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Nagy, O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R. M. Costa, A. J. Silva, L. Kaczmarek, and G. W. Huntley
Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory
J. Neurosci., February 15, 2006; 26(7): 1923 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Shi and I. M. Ethell
Integrins Control Dendritic Spine Plasticity in Hippocampal Neurons through NMDA Receptor and Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Actin Reorganization
J. Neurosci., February 8, 2006; 26(6): 1813 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. R. Gingrich, K. A. Pelkey, S. R. Fam, Y. Huang, R. S. Petralia, R. J. Wenthold, and M. W. Salter
Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2
PNAS, April 20, 2004; 101(16): 6237 - 6242.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Kawasaki, G. E. Davis, and M. J. Davis
Regulation of Ca2+-dependent K+ Current by {alpha}v{beta}3 Integrin Engagement in Vascular Endothelium
J. Biol. Chem., March 26, 2004; 279(13): 12959 - 12966.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online