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J Neurophysiol 89: 3097-3113, 2003; doi:10.1152/jn.00127.2002
0022-3077/03 $5.00
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The Roles Potassium Currents Play in Regulating the Electrical Activity of Ventral Cochlear Nucleus Neurons

Jason S. Rothman1 and Paul B. Manis2

The Center for Hearing Science, 1 Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; and 2Department of Otolaryngology/Head and Neck Surgery, and The Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina 27599

Using kinetic data from three different K+ currents in acutely isolated neurons, a single electrical compartment representing the soma of a ventral cochlear nucleus (VCN) neuron was created. The K+ currents include a fast transient current (IA), a slow-inactivating low-threshold current (ILT), and a noninactivating high-threshold current (IHT). The model also includes a fast-inactivating Na+ current, a hyperpolarization-activated cation current (Ih), and 1–50 auditory nerve synapses. With this model, the role IA, ILT, and IHT play in shaping the discharge patterns of VCN cells is explored. Simulation results indicate that IHT mainly functions to repolarize the membrane during an action potential, and IA functions to modulate the rate of repetitive firing. ILT is found to be responsible for the phasic discharge pattern observed in Type II cells (bushy cells). However, by adjusting the strength of ILT, both phasic and regular discharge patterns are observed, demonstrating that a critical level of ILT is necessary to produce the Type II response. Simulated Type II cells have a significantly faster membrane time constant in comparison to Type I cells (stellate cells) and are therefore better suited to preserve temporal information in their auditory nerve inputs by acting as precise coincidence detectors and having a short refractory period. Finally, we demonstrate that modulation of Ih, which changes the resting membrane potential, is a more effective means of modulating the activation level of ILT than simply modulating ILT itself. This result may explain why ILT and Ih are often coexpressed throughout the nervous system.

Address for reprint requests: Paul B. Manis, Dept. Otolaryngology/Head and Neck Surgery, 1123 Bioinformatics Bldg., CB#7070, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7070 (E-mail: pmanis{at}med.unc.edu).




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