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Single-Pulse Transcranial Magnetic Stimulation of Parietal and Prefrontal Areas in a Memory Delay Arm Pointing Task

¹Cognition and Action Group, Neurology and Psychiatry Department and ³Laboratory of Electromyography, Neurology Department, National University of Athens, Aeginition Hospital, Athens GR-11528, Greece; and ²Eye Movement Research Laboratory, Neurology Department, University of Bern, Inselspital, CH-3010 Bern, Switzerland

Submitted 13 September 2002; accepted in final form 6 February 2003

Fifteen healthy volunteers performed a memory-pointing task using their right arm while single-pulse transcranial magnetic stimulation (TMS) above motor threshold was applied over the posterior parietal or prefrontal cortex of the left or right hemisphere in four blocks of trials. The stimulation was randomly delivered at one of three time intervals during the 3-s delay period (early: 300 ms, intermediate: 1,500 ms, late: 2,700 ms). A separate block with no stimulation was used as control. Only early left parietal stimulation resulted in an increase in the variance of movement amplitude but not direction for all targets in two-dimensional space (both hemifields). The results point to the significance of the contralateral posterior parietal cortex early on during the memorization of the target for an upcoming movement. Taking into consideration the limitations of TMS and those imposed by the particular task, the lack of specific effects of prefrontal stimulation provides evidence that these areas might not be involved in the performance of simple memorized arm movements.

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