| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD; and 2Oxford Centre for Functional Magnetic Resonance Imaging (FMRIB), John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Submitted 13 August 2002; accepted in final form 1 February 2003
Umami taste stimuli, of which an exemplar is monosodium glutamate (MSG) and which capture what is described as the taste of protein, were shown using functional MRI (fMRI) to activate similar cortical regions of the human taste system to those activated by a prototypical taste stimulus, glucose. These taste regions included the insular/opercular cortex and the caudolateral orbitofrontal cortex. A part of the rostral anterior cingulate cortex (ACC) was also activated. When the nucleotide 0.005 M inosine 5'-monophosphate (IMP) was added to MSG (0.05 M), the blood oxygenation-level dependent (BOLD) signal in an anterior part of the orbitofrontal cortex showed supralinear additivity; this may reflect the subjective enhancement of umami taste that has been described when IMP is added to MSG. These results extend to humans previous studies in macaques showing that single neurons in these taste cortical areas can be tuned to umami stimuli.
This article has been cited by other articles:
|
|
 |
|
  F. Grabenhorst, E. T. Rolls, and A. Bilderbeck How Cognition Modulates Affective Responses to Taste and Flavor: Top-down Influences on the Orbitofrontal and Pregenual Cingulate Cortices Cereb Cortex, July 1, 2008; 18(7): 1549 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. McCabe, E. T. Rolls, A. Bilderbeck, and F. McGlone Cognitive influences on the affective representation of touch and the sight of touch in the human brain Soc Cogn Affect Neurosci, June 1, 2008; 3(2): 97 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Rolls, C. McCabe, and J. Redoute Expected Value, Reward Outcome, and Temporal Difference Error Representations in a Probabilistic Decision Task Cereb Cortex, March 1, 2008; 18(3): 652 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Grabenhorst, E. T. Rolls, C. Margot, M. A. A. P. da Silva, and M. I. Velazco How Pleasant and Unpleasant Stimuli Combine in Different Brain Regions: Odor Mixtures J. Neurosci., December 5, 2007; 27(49): 13532 - 13540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Veldhuizen, G. Bender, R. T. Constable, and D. M. Small Trying to Detect Taste in a Tasteless Solution: Modulation of Early Gustatory Cortex by Attention to Taste Chem Senses, July 1, 2007; 32(6): 569 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wifall, T. Faes, C. Taylor-Burds, J. Mitzelfelt, and E. Delay An Analysis of 5'-Inosine and 5'-Guanosine Monophosphate Taste in Rats Chem Senses, February 1, 2007; 32(2): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Onoda, T. Kobayakawa, M. Ikeda, S. Saito, and A. Kida Laterality of Human Primary Gustatory Cortex Studied by MEG Chem Senses, October 1, 2005; 30(8): 657 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Simmons, A. Martin, and L. W. Barsalou Pictures of Appetizing Foods Activate Gustatory Cortices for Taste and Reward Cereb Cortex, October 1, 2005; 15(10): 1602 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kadohisa, E. T. Rolls, and J. V. Verhagen Neuronal Representations of Stimuli in the Mouth: The Primate Insular Taste Cortex, Orbitofrontal Cortex and Amygdala Chem Senses, June 1, 2005; 30(5): 401 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Rolls Taste and Related Systems in Primates Including Humans Chem Senses, January 1, 2005; 30(suppl_1): i76 - i77. [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Verhagen, M. Kadohisa, and E. T. Rolls Primate Insular/Opercular Taste Cortex: Neuronal Representations of the Viscosity, Fat Texture, Grittiness, Temperature, and Taste of Foods J Neurophysiol, September 1, 2004; 92(3): 1685 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E. de Araujo and E. T. Rolls Representation in the Human Brain of Food Texture and Oral Fat J. Neurosci., March 24, 2004; 24(12): 3086 - 3093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Rolls, J. V. Verhagen, and M. Kadohisa Representations of the Texture of Food in the Primate Orbitofrontal Cortex: Neurons Responding to Viscosity, Grittiness, and Capsaicin J Neurophysiol, December 1, 2003; 90(6): 3711 - 3724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E.T. de Araujo, M. L. Kringelbach, E. T. Rolls, and F. McGlone Human Cortical Responses to Water in the Mouth, and the Effects of Thirst J Neurophysiol, September 1, 2003; 90(3): 1865 - 1876. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
