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1 Abteilung Neurophysiologie, Max-Planck-Institut für Hirnforschung, 60528 Frankfurt; 2 Abt. Klinische Neurobiologie, Universität Heidelberg, 69120 Heidelberg; 3 Institut für Neurophysiologie und Pathophysiologie, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany
Submitted 1 July 2002; accepted in final form 31 March 2003
Synchronization of neuronal discharges has been hypothesized to play a role
in defining cell assemblies representing particular constellations of stimulus
features. In many systems and species, synchronization is accompanied by an
oscillatory response modulation at frequencies in the 
-band. The
cellular mechanisms underlying these phenomena of synchronization and
oscillatory patterning have been studied mainly in vitro due to the difficulty
in designing a direct in vivo assay. With the prospect of using conditional
genetic manipulations of cortical network components, our objective was to
test whether the mouse would meet the criteria to provide a model system for
the study of -band synchrony. Multi-unit and local field potential
recordings were made from the primary visual cortex of anesthetized C57BL/6J
mice. Neuronal responses evoked by moving gratings, bars, and random dot
patterns were analyzed with respect to neuronal synchrony and temporal
patterning. Oscillations at -frequencies were readily evoked with all
types of stimuli used. Oscillation and synchronization strength were largest
for gratings and decreased when the noise level was increased in random-dot
patterns. The center peak width of cross-correlograms was smallest for bars
and increased with noise, yielding a significant difference between coherent
random dot patterns versus patterns with 70% noise. Field potential analysis
typically revealed increases of power in the -band during response
periods. Our findings are compatible with a role for neuronal synchrony in
mediating perceptual binding and suggest the usefulness of the mouse model for
testing hypotheses concerning both the mechanisms and the functional role of
temporal patterning.
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