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Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, Netherlands
Submitted 30 September 2002; accepted in final form 8 April 2003
The dynamic properties of synapses between neurons in the hippocampal CA1
area are important for the frequency-dependent signal transfer of the network.
We have examined the synaptic dynamics of excitatory inputs to CA1
interneurons and pyramidal cells using whole cell voltage-clamp recordings.
The CA1 network was activated using extracellular stimulation electrodes at
the Schaffer collaterals (feedforward activation) or at the Alveus (activation
of the feedback loop). The dynamic properties of input from the Schaffer
collaterals to CA1 interneurons (basket and bistratified cells) were different
from the synaptic dynamics of input from the Alveus. Synaptic input from the
Schaffer collaterals to CA1 interneurons showed facilitation for most
frequencies. After 10 stimuli the synaptic response reached a plateau level
that was 
150% of the first response in the train. In contrast, the
plateau levels of Alveus inputs to interneurons were not different from the
first responses for frequencies 
40 Hz. Paired-pulse facilitation of
Schaffer input was stronger than for Alveus input. Cells in stratum oriens
with horizontal dendritic trees appeared to be a special group of interneurons
because Alveus input to these cells showed strong facilitation with plateau
levels of 200% of the first responses. Schaffer input to CA1 basket and
bistratified cells showed similar synaptic dynamics compared with Schaffer
input to pyramidal cells for frequencies 80 Hz. The synaptic dynamics of
Schaffer and Alveus input depended only weakly on the stimulus intensity. The
difference between the dynamics of Alveus and Schaffer input to CA1
interneurons implies that the relative contribution of feedforward and -back
inhibition to network activity depends on the frequency of the input signal at
the afferent fibers, adding a level of complexity to transient responses.
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