| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Laboratoire de Neurobiologie des Réseaux Sensorimoteurs, Centre National de la Recherche Scientifique UMR 7060, Université Paris 5, Centre Universitaire des Saints-Pères, 75270 Paris Cédex 06, France; 2 The Rockefeller University, New York, New York 10021
Submitted 3 March 2003; accepted in final form 8 May 2003
In vitro intracellular recordings of central vestibular neurons have been restricted so far to the medial vestibular nucleus (MVN). We performed intracellular recordings of large Deiters' neurons in the lateral vestibular nucleus (LVN) to determine their static and dynamic membrane properties, and compare them with those of type A and type B neurons identified in the MVN. Unlike MVN neurons (MVNn), the giant-size LVN neurons (LVNn) form a homogeneous population of cells characterized by sharp spikes, a low-amplitude, biphasic after-hyperpolarization like type B MVNn, but also an A-like rectification like type A MVNn. In accordance with their lower membrane resistance, the sensitivity of LVNn to current injection was lower than that of MVNn over a large range of frequencies. The main difference between LVNn and MVNn was that the Bode plots showing the sensitivity of LVNn as a function of stimulation frequency were flatter than those of MVNn, and displayed a weaker resonance. Furthermore, most LVNn did not show a gradual decrease of their firing rate modulation in the frequency range where it was observed in MVNn. LVNn synchronized their firing with the depolarizing phase of high-frequency sinusoidal current injections. In vivo studies have shown that the MVN would be mainly involved in gaze control, whereas the giant LVNn that project to the spinal cord are involved in the control of posture. We suggest that the difference in the membrane properties of LVNn and MVNn may reflect their specific physiological roles.
This article has been cited by other articles:
|
|
 |
|
  N. Pilati, M. Barker, S. Panteleimonitis, R. Donga, and M. Hamann A Rapid Method Combining Golgi and Nissl Staining to Study Neuronal Morphology and Cytoarchitecture J. Histochem. Cytochem., June 1, 2008; 56(6): 539 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Eugene, S. Deforges, F. Guimont, E. Idoux, P.-P. Vidal, L. E. Moore, and N. Vibert Developmental regulation of the membrane properties of central vestibular neurons by sensory vestibular information in the mouse J. Physiol., September 15, 2007; 583(3): 923 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Idoux, M. Serafin, P. Fort, P.-P. Vidal, M. Beraneck, N. Vibert, M. Muhlethaler, and L. E. Moore Oscillatory and Intrinsic Membrane Properties of Guinea Pig Nucleus Prepositus Hypoglossi Neurons In Vitro J Neurophysiol, July 1, 2006; 96(1): 175 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sekirnjak and S. du Lac Physiological and Anatomical Properties of Mouse Medial Vestibular Nucleus Neurons Projecting to the Oculomotor Nucleus J Neurophysiol, May 1, 2006; 95(5): 3012 - 3023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Beraneck, E. Idoux, A. Uno, P.-P. Vidal, L. E. Moore, and N. Vibert Unilateral Labyrinthectomy Modifies the Membrane Properties of Contralesional Vestibular Neurons J Neurophysiol, September 1, 2004; 92(3): 1668 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Straka, M. Beraneck, M. Rohregger, L. E. Moore, P.-P. Vidal, and N. Vibert Second-Order Vestibular Neurons Form Separate Populations With Different Membrane and Discharge Properties J Neurophysiol, August 1, 2004; 92(2): 845 - 861. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
