HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Jiang, W. Articles by Stein, B. E. Search for Related Content PubMed PubMed Citation Articles by Jiang, W. Articles by Stein, B. E.

Cortex Controls Multisensory Depression in Superior Colliculus

Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157

Submitted 14 April 2003; accepted in final form 9 July 2003

Multisensory depression is a fundamental index of multisensory integration in superior colliculus (SC) neurons. It is initiated when one sensory stimulus (auditory) located outside its modality-specific receptive field degrades or eliminates the neuron's responses to another sensory stimulus (visual) presented within its modality-specific receptive field. The present experiments demonstrate that the capacity of SC neurons to engage in multisensory depression is strongly dependent on influences from two cortical areas (the anterior ectosylvian and rostral lateral suprasylvian sulci). When these cortices are deactivated, the ability of SC neurons to synthesize visual-auditory inputs in this way is compromised; multisensory responses are disinhibited, becoming more vigorous and in some cases indistinguishable from responses to the visual stimulus alone. Although obtaining a more robust multisensory SC response when cortex is nonfunctional than when it is functional may seem paradoxical, these data may help explain previous observations that the loss of these cortical influences permits visual orientation behavior in the presence of a normally disruptive auditory stimulus.

This article has been cited by other articles:

				V. Fuentes-Santamaria, J. C. Alvarado, B. E. Stein, and J. G. McHaffie Cortex Contacts both Output Neurons and Nitrergic Interneurons in the Superior Colliculus: Direct and Indirect Routes for Multisensory Integration Cereb Cortex, July 1, 2008; 18(7): 1640 - 1652. [Abstract] [Full Text] [PDF]

				E. LADAVAS Multisensory-based Approach to the Recovery of Unisensory Deficit Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 98 - 110. [Abstract] [Full Text] [PDF]

				F. Leo, N. Bolognini, C. Passamonti, B. E. Stein, and E. Ladavas Cross-modal localization in hemianopia: new insights on multisensory integration Brain, March 1, 2008; 131(3): 855 - 865. [Abstract] [Full Text] [PDF]

				J. C. Alvarado, T. R. Stanford, J. W. Vaughan, and B. E. Stein Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus J. Neurosci., November 21, 2007; 27(47): 12775 - 12786. [Abstract] [Full Text] [PDF]

				J. C. Alvarado, J. W. Vaughan, T. R. Stanford, and B. E. Stein Multisensory Versus Unisensory Integration: Contrasting Modes in the Superior Colliculus J Neurophysiol, May 1, 2007; 97(5): 3193 - 3205. [Abstract] [Full Text] [PDF]

				D. Talsma, T. J. Doty, and M. G. Woldorff Selective Attention and Audiovisual Integration: Is Attending to Both Modalities a Prerequisite for Early Integration? Cereb Cortex, March 1, 2007; 17(3): 679 - 690. [Abstract] [Full Text] [PDF]

				W. Jiang, H. Jiang, B. A. Rowland, and B. E. Stein Multisensory Orientation Behavior Is Disrupted by Neonatal Cortical Ablation J Neurophysiol, January 1, 2007; 97(1): 557 - 562. [Abstract] [Full Text] [PDF]

				W. Jiang, H. Jiang, and B. E. Stein Neonatal Cortical Ablation Disrupts Multisensory Development in Superior Colliculus J Neurophysiol, March 1, 2006; 95(3): 1380 - 1396. [Abstract] [Full Text] [PDF]

				M. M. Murray, S. Molholm, C. M. Michel, D. J. Heslenfeld, W. Ritter, D. C. Javitt, C. E. Schroeder, and J. J. Foxe Grabbing Your Ear: Rapid Auditory-Somatosensory Multisensory Interactions in Low-level Sensory Cortices Are Not Constrained by Stimulus Alignment Cereb Cortex, July 1, 2005; 15(7): 963 - 974. [Abstract] [Full Text] [PDF]

				T. J. Perrault Jr., J. W. Vaughan, B. E. Stein, and M. T. Wallace Superior Colliculus Neurons Use Distinct Operational Modes in the Integration of Multisensory Stimuli J Neurophysiol, May 1, 2005; 93(5): 2575 - 2586. [Abstract] [Full Text] [PDF]

				N. E. Barraclough, D. Xiao, C. I. Baker, M. W. Oram, and D. I. Perrett Integration of Visual and Auditory Information by Superior Temporal Sulcus Neurons Responsive to the Sight of Actions J. Cogn. Neurosci., March 1, 2005; 17(3): 377 - 391. [Abstract] [Full Text] [PDF]