JN Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 90: 2171-2179, 2003. First published June 18, 2003; doi:10.1152/jn.01177.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
90/4/2171    most recent
01177.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oh, M. M.
Right arrow Articles by Disterhoft, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oh, M. M.
Right arrow Articles by Disterhoft, J. F.

Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons

M. Matthew Oh*, Amy G. Kuo*, Wendy W. Wu, Evgeny A. Sametsky and John F. Disterhoft

Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611

Submitted 30 December 2002; accepted in final form 12 June 2003

The dorsal hippocampus is crucial for learning the hidden-platform location in the hippocampus-dependent, spatial watermaze task. We have previously demonstrated that the postburst afterhyperpolarization (AHP) of hippocampal pyramidal neurons is reduced after acquisition of the hippocampus-dependent, temporal trace eyeblink conditioning task. We report here that the AHP and one or more of its associated currents (IAHP and/or sIAHP) are reduced in dorsal hippocampal CA1 pyramidal neurons from rats that learned the watermaze task as compared with neurons from control rats. This reduction was a learning-induced phenomenon as the AHP of CA1 neurons from rats that failed to learn the hidden-platform location was similar to that of neurons from control rats. We propose that reduction of the AHP in pyramidal neurons in regions crucial for learning is a cellular mechanism of learning that is conserved across species and tasks.

Address for reprint requests and other correspondence: M. M. Oh or A. G. Kuo, Dept. of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Chicago, IL 60611 (E-mail: mattoh{at}northwestern.edu or a-gamelli{at}northwestern.edu).




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
N. G. Jin, L.-M. Tian, and T. Crow
5-HT and GABA Modulate Intrinsic Excitability of Type I Interneurons in Hermissenda
J Neurophysiol, November 1, 2009; 102(5): 2825 - 2833.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. M. McKay, E. A. Matthews, F. A. Oliveira, and J. F. Disterhoft
Intrinsic Neuronal Excitability Is Reversibly Altered by a Single Experience in Fear Conditioning
J Neurophysiol, November 1, 2009; 102(5): 2763 - 2770.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
C. C. Kaczorowski and J. F. Disterhoft
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice
Learn. Mem., May 23, 2009; 16(6): 362 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. A. Matthews, J. M. Linardakis, and J. F. Disterhoft
The Fast and Slow Afterhyperpolarizations Are Differentially Modulated in Hippocampal Neurons by Aging and Learning
J. Neurosci., April 15, 2009; 29(15): 4750 - 4755.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. M. Oh, B. M. McKay, J. M. Power, and J. F. Disterhoft
Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A
PNAS, February 3, 2009; 106(5): 1620 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
E. A. Matthews and J. F. Disterhoft
Blocking the BK channel impedes acquisition of trace eyeblink conditioning
Learn. Mem., January 29, 2009; 16(2): 106 - 109.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. W. Wu, C. S. Chan, D. J. Surmeier, and J. F. Disterhoft
Coupling of L-Type Ca2+ Channels to KV7/KCNQ Channels Creates a Novel, Activity-Dependent, Homeostatic Intrinsic Plasticity
J Neurophysiol, October 1, 2008; 100(4): 1897 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. A. Matthews, A. P. Weible, S. Shah, and J. F. Disterhoft
The BK-mediated fAHP is modulated by learning a hippocampus-dependent task
PNAS, September 30, 2008; 105(39): 15154 - 15159.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Santini, G. J. Quirk, and J. T. Porter
Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons
J. Neurosci., April 9, 2008; 28(15): 4028 - 4036.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. R. Young, R. Bianchi, and R. K. S. Wong
Signaling Mechanisms Underlying Group I mGluR-Induced Persistent AHP Suppression in CA3 Hippocampal Neurons
J Neurophysiol, March 1, 2008; 99(3): 1105 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. D. Burrell and K. M. Crisp
Serotonergic Modulation of Afterhyperpolarization in a Neuron That Contributes to Learning in the Leech
J Neurophysiol, February 1, 2008; 99(2): 605 - 616.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Lopez de Armentia, D. Jancic, R. Olivares, J. M. Alarcon, E. R. Kandel, and A. Barco
cAMP Response Element-Binding Protein-Mediated Gene Expression Increases the Intrinsic Excitability of CA1 Pyramidal Neurons
J. Neurosci., December 12, 2007; 27(50): 13909 - 13918.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. I. Cohen-Matsliah, I. Brosh, K. Rosenblum, and E. Barkai
A Novel Role for Extracellular Signal-Regulated Kinase in Maintaining Long-Term Memory-Relevant Excitability Changes
J. Neurosci., November 14, 2007; 27(46): 12584 - 12589.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. Antunes-Martins, K. Mizuno, E. E. Irvine, E. M. Lepicard, and K. P. Giese
Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation
Learn. Mem., October 1, 2007; 14(10): 693 - 702.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. C. Kaczorowski, J. Disterhoft, and N. Spruston
Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions
J. Physiol., February 1, 2007; 578(3): 799 - 818.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Martina, M.-E. B. Turcotte, S. Halman, and R. Bergeron
The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus
J. Physiol., January 1, 2007; 578(1): 143 - 157.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Brosh, K. Rosenblum, and E. Barkai
Learning-Induced Reversal of the Effect of Noradrenalin on the Postburst AHP
J Neurophysiol, October 1, 2006; 96(4): 1728 - 1733.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
I. Zelcer, H. Cohen, G. Richter-Levin, T. Lebiosn, T. Grossberger, and E. Barkai
A Cellular Correlate of Learning-induced Metaplasticity in the Hippocampus
Cereb Cortex, April 1, 2006; 16(4): 460 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. G. Kuo, G. Lee, and J. F. Disterhoft
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning.
Learn. Mem., March 1, 2006; 13(2): 201 - 207.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. S. Hammond, C. T. Bond, T. Strassmaier, T. Jennifer Ngo-Anh, J. P. Adelman, J. Maylie, and R. W. Stackman
Small-Conductance Ca2+-Activated K+ Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity
J. Neurosci., February 8, 2006; 26(6): 1844 - 1853.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. D. Burrell and C. L. Sahley
Serotonin Mediates Learning-Induced Potentiation of Excitability
J Neurophysiol, December 1, 2005; 94(6): 4002 - 4010.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. C. Tombaugh, W. B. Rowe, and G. M. Rose
The Slow Afterhyperpolarization in Hippocampal CA1 Neurons Covaries with Spatial Learning Ability in Aged Fisher 344 Rats
J. Neurosci., March 9, 2005; 25(10): 2609 - 2616.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
C. Weiss, E. Sametsky, A. Sasse, J. Spiess, and J. F. Disterhoft
Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons
Learn. Mem., March 1, 2005; 12(2): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang
Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., February 16, 2005; 25(7): 1750 - 1760.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. H. Cudmore and G. G. Turrigiano
Long-Term Potentiation of Intrinsic Excitability in LV Visual Cortical Neurons
J Neurophysiol, July 1, 2004; 92(1): 341 - 348.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the The American Physiological Society.