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Mammalian Retinal Bipolar Cells Express Inwardly Rectifying K⁺ Currents (I_Kir) With a Different Distribution Than That of I_h

Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201

Submitted 5 May 2003; accepted in final form 23 June 2003

Retinal bipolar cells comprise multiple subtypes that are well known for the diversity of their physiological properties. We investigated the properties and functional roles of the hyperpolarization-activated currents in mammalian retinal bipolar cells using whole cell patch-clamp recording techniques. We report that bipolar cells express inwardly rectifying K⁺ currents (I_Kir) in addition to the hyperpolarization-activated cationic currents (I_h) previously reported. Furthermore, these two currents are differentially expressed among different subtypes of bipolar cells. One group of cone bipolar cells in particular displayed mainly I_Kir. A second group of cone bipolar cells displayed both currents but with a much larger I_h. Rod bipolar cells, on the other hand, showed primarily I_h. Moreover, we showed that I_Kir and I_h differentially influence the voltage responses of bipolar cells: I_h facilitates and/or accelerates the membrane potential rebound, whereas I_Kir counteracts or prevents such rebound. The findings of the expression of I_Kir and the differential expression of I_h and I_Kir in bipolar cells may provide new insights into an understanding of the physiological properties of bipolar cells.

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