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J Neurophysiol 91: 163-171, 2004. First published October 1, 2003; doi:10.1152/jn.00680.2003
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Role of the Tectorial Membrane Revealed by Otoacoustic Emissions Recorded From Wild-Type and Transgenic Tecta{Delta}ENT/{Delta}ENT Mice

Andrei N. Lukashkin, Victoria A. Lukashkina, P. Kevin Legan, Guy P. Richardson and Ian J. Russell

School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom

Submitted 15 July 2003; accepted in final form 24 September 2003

Distortion product otoacoustic emissions (DPOAE) were recorded from wild-type mice and mutant Tecta{Delta}ENT/{Delta}ENT mice with detached tectorial membranes (TM) under combined ketamine/xylaxine anesthesia. In Tecta{Delta}ENT/{Delta}ENT mice, DPOAEs could be detected above the noise floor only when the levels of the primary tones exceeded 65 dB SPL. DPOAE amplitude decreased with increasing frequency of the primaries in Tecta{Delta}ENT/{Delta}ENT mice. This was attributed to hair cell excitation via viscous coupling to the surrounding fluid and not by interaction with the TM as in the wild-type mice. Local minima and corresponding phase transitions in the DPOAE growth functions occurred at higher DPOAE levels in wild-type than in Tecta{Delta}ENT/{Delta}ENT mice. In less-sensitive Tecta{Delta}ENT/{Delta}ENT mice, the position of the local minima varied nonsystematically with frequency or no minima were observed. A bell-like dependence of the DPOAE amplitude on the ratio of the primaries was recorded in both wild-type and Tecta{Delta}ENT/{Delta}ENT mice. However, the pattern of this dependence was different in the wild-type and Tecta{Delta}ENT/{Delta}ENT mice, an indication that the bell-like shape of the DPOAE was produced by a combination of different mechanisms. A nonlinear low-frequency resonance, revealed by nonmonotonicity of the phase behavior, was seen in the wild-type but not in Tecta{Delta}ENT/{Delta}ENT mice.

Address for reprint requests and other correspondence: A. N. Lukashkin, School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK (E-mail: a.lukashkin{at}sussex.ac.uk).




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M. Drexl, M. M. Mellado Lagarde, J. Zuo, A. N. Lukashkin, and I. J. Russell
The Role of Prestin in the Generation of Electrically Evoked Otoacoustic Emissions in Mice
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