JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 91: 267-273, 2004; doi:10.1152/jn.00314.2003
0022-3077/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kononenko, N. I.
Right arrow Articles by Dudek, F. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kononenko, N. I.
Right arrow Articles by Dudek, F. E.

Mechanism of Irregular Firing of Suprachiasmatic Nucleus Neurons in Rat Hypothalamic Slices

Nikolai I. Kononenko and F. Edward Dudek

Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523

Submitted 31 March 2003; accepted in final form 23 June 2003

The mechanisms of irregular firing of spontaneous action potentials in neurons from the rat suprachiasmatic nucleus (SCN) were studied in hypothalamic slices using cell-attached and whole cell recording. The firing pattern of spontaneous action potentials could be divided into regular and irregular, based on the interspike interval (ISI) histogram and the membrane potential trajectory between action potentials. Similar to previous studies, regular neurons had a firing rate about >3.5 Hz and irregular neurons typically fired about <3.5 Hz. The ISI of irregular-firing neurons was a linear function of the sum of inhibitory postsynaptic potentials (IPSPs) between action potentials. Bicuculline (10–30 µM) suppressed IPSPs and converted an irregular pattern to a more regular firing. Bicuculline also depolarized SCN neurons and induced bursting-like activity in some SCN neurons. Gabazine (20 µM), however, suppressed IPSPs without depolarization, and also converted irregular activity to regular firing. Thus GABAA receptor–mediated IPSPs appear responsible for irregular firing of SCN neurons in hypothalamic slices.

Address for reprint requests and other correspondence: F. E. Dudek, Department of Biomedical Sciences, Section of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523 (E-mail: ed.dudek{at}colostate.edu).




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
C. A. A. Penatti, D. M. Porter, and L. P. Henderson
Chronic Exposure to Anabolic Androgenic Steroids Alters Neuronal Function in the Mammalian Forebrain via Androgen Receptor- and Estrogen Receptor-Mediated Mechanisms
J. Neurosci., October 7, 2009; 29(40): 12484 - 12496.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. B. Park, J. Y. Jo, H. Zheng, K. P. Patel, and J. E. Stern
Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters
J. Physiol., October 1, 2009; 587(19): 4645 - 4660.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
C. O. Diekman and D. B. Forger
Clustering Predicted by an Electrophysiological Model of the Suprachiasmatic Nucleus
J Biol Rhythms, August 1, 2009; 24(4): 322 - 333.
[Abstract] [PDF]

Home page
 J Biol RhythmsHome page
Y. Kwak, G. B. Lundkvist, J. Brask, A. Davidson, M. Menaker, K. Kristensson, and G. D. Block
Interferon-{gamma} Alters Electrical Activity and Clock Gene Expression in Suprachiasmatic Nucleus Neurons
J Biol Rhythms, April 1, 2008; 23(2): 150 - 159.
[Abstract] [PDF]

Home page
 J Biol RhythmsHome page
Choon Kiat Sim and D. B. Forger
Modeling the Electrophysiology of Suprachiasmatic Nucleus Neurons
J Biol Rhythms, October 1, 2007; 22(5): 445 - 453.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
J. B. Park, S. Skalska, S. Son, and J. E. Stern
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons
J. Physiol., July 15, 2007; 582(2): 539 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Li, P. K. Tripathi, and W. E. Armstrong
Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity
J. Physiol., May 15, 2007; 581(1): 221 - 240.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. J. Aton, J. E. Huettner, M. Straume, and E. D. Herzog
GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons
PNAS, December 12, 2006; 103(50): 19188 - 19193.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. E. Hallworth and M. D. Bevan
Globus Pallidus Neurons Dynamically Regulate the Activity Pattern of Subthalamic Nucleus Neurons through the Frequency-Dependent Activation of Postsynaptic GABAA and GABAB Receptors
J. Neurosci., July 6, 2005; 25(27): 6304 - 6315.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Cui, T. Okamoto, and H. Morikawa
Spontaneous Opening of T-Type Ca2+ Channels Contributes to the Irregular Firing of Dopamine Neurons in Neonatal Rats
J. Neurosci., December 8, 2004; 24(49): 11079 - 11087.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. C. Jackson, G. L. Yao, and B. P. Bean
Mechanism of Spontaneous Firing in Dorsomedial Suprachiasmatic Nucleus Neurons
J. Neurosci., September 15, 2004; 24(37): 7985 - 7998.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.