HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 91/2/1078    most recent 00205.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Das, V. E. Articles by Mustari, M. J. Search for Related Content PubMed PubMed Citation Articles by Das, V. E. Articles by Mustari, M. J.

Report

Conjugate Adaptation of Saccadic Gain in Non-Human Primates With Strabismus

¹Division of Visual Science, Yerkes National Primate Research Center, and ²Department of Neurology, Emory University, Atlanta, Georgia 30322

Submitted 4 March 2003; accepted in final form 27 October 2003

In this study, we have used the double-step paradigm to test saccadic gain adaptation during monocular viewing in one normal monkey, two monkeys with exotropia, and one monkey with esotropia. In this paradigm, the target for the saccade is displaced during the saccade, resulting in a consistent visual error. Studies in normal humans and monkeys have shown that the brain responds to this consistent visual error by gradually changing saccade gain. Using this technique, we were able to elicit adaptation in both the viewing eye and the nonviewing eye in the normal monkey and in monkeys with strabismus. The rate of adaptation was not significantly different in the viewing and nonviewing eyes in the normal and strabismic monkeys. The magnitude of adaptation as calculated by a percentage change in gain was also not significantly different in the viewing and the nonviewing eyes in the normal and strabismic monkeys. Our data show that animals with strabismus retain the ability to elicit a conjugate adaptation of saccades using this mechanism. We also suggest that the double-step paradigm elicits a conjugate adaptation of saccades whether the animal is viewing monocularly (our studies) or binocularly (data published in literature).

This article has been cited by other articles:

				J. R. Economides, D. L. Adams, C. M. Jocson, and J. C. Horton Ocular Motor Behavior in Macaques With Surgical Exotropia J Neurophysiol, December 1, 2007; 98(6): 3411 - 3422. [Abstract] [Full Text] [PDF]

				L. Fu, R. J. Tusa, M. J. Mustari, and V. E. Das Horizontal Saccade Disconjugacy in Strabismic Monkeys Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3107 - 3114. [Abstract] [Full Text] [PDF]