JN AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 91: 1832-1839, 2004. First published November 5, 2003; doi:10.1152/jn.00820.2003
0022-3077/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
91/4/1832    most recent
00820.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alstermark, B.
Right arrow Articles by Isa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alstermark, B.
Right arrow Articles by Isa, T.

Lack of Monosynaptic Corticomotoneuronal EPSPs in Rats: Disynaptic EPSPs Mediated Via Reticulospinal Neurons and Polysynaptic EPSPs Via Segmental Interneurons

B. Alstermark1, J. Ogawa2 and T. Isa3

1 Department of Integrative Medical Biology, Section of Physiology, Umeå University, S-901 87 Umeå, Sweden 2 Department of Orthopaedic Surgery, Kyorin University School of Medicine, Mitaka-shi, 181-8611, Japan 3 Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, 444-8585 Okazaki, Japan

Submitted 21 August 2003; accepted in final form 29 October 2003

In the rat, some findings have been taken to suggest the existence of monosynaptic corticomotoneuronal (CM) connections. Because this connection is believed to be largely responsible for the ability to make independent digit movements in primates and man, it has been inferred that the monosynaptic CM connection in the rat is likewise important for skilled prehension. Comparison of intra- and extracellular recordings from forelimb motoneurons in anesthetized rats, revealed no monosynaptic CM excitatory postsynaptic potentials (EPSPs). The fastest descending excitation in forelimb motoneurons was disynaptically mediated via a corticoreticulospinal pathway and slowly conducted excitation via corticospinal fibers and segmental interneurons. The findings stress the importance of di- and trisynaptic excitatory corticofugal pathways to forelimb motoneurons in the control of skilful digit movements.

Address for reprint requests and other correspondence: B. Alstermark, Dept. of Integrative Medical Biology, Section of Physiology, University of Umeå, S-901 87 Umeå, Sweden (E-mail: Bror.Alstermark{at}physiol.umu.se).




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. Brus-Ramer, J. B. Carmel, S. Chakrabarty, and J. H. Martin
Electrical Stimulation of Spared Corticospinal Axons Augments Connections with Ipsilateral Spinal Motor Circuits after Injury
J. Neurosci., December 12, 2007; 27(50): 13793 - 13801.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Pan, M. R. Zahner, E. Kulikowicz, and L. P. Schramm
Effects of corticospinal tract stimulation on renal sympathetic nerve activity in rats with intact and chronically lesioned spinal cords
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R178 - R184.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
T. Isa, Y. Ohki, B. Alstermark, L.-G. Pettersson, and S. Sasaki
Direct and Indirect Cortico-Motoneuronal Pathways and Control of Hand/Arm Movements
Physiology, April 1, 2007; 22(2): 145 - 152.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Kamiyama, N. Yoshioka, and M. Sakurai
Synapse Elimination in the Corticospinal Projection During the Early Postnatal Period
J Neurophysiol, April 1, 2006; 95(4): 2304 - 2313.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Grinevich, M. Brecht, and P. Osten
Monosynaptic Pathway from Rat Vibrissa Motor Cortex to Facial Motor Neurons Revealed by Lentivirus-Based Axonal Tracing
J. Neurosci., September 7, 2005; 25(36): 8250 - 8258.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Lemon, S. Sasaki, K. Naito, K. Yoshimura, T. Isa, K. Seki, L.-G. Pettersson, B. Alstermark, and Y. Ohki
Cortico-motoneuronal system and dexterous finger movements
J Neurophysiol, December 1, 2004; 92(6): 3601 - 3603.
[Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Alstermark and J. Ogawa
In Vivo Recordings of Bulbospinal Excitation in Adult Mouse Forelimb Motoneurons
J Neurophysiol, September 1, 2004; 92(3): 1958 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. J. Kargo and D. A. Nitz
Improvements in the Signal-to-Noise Ratio of Motor Cortex Cells Distinguish Early versus Late Phases of Motor Skill Learning
J. Neurosci., June 16, 2004; 24(24): 5560 - 5569.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.