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J Neurophysiol 91: 2273-2280, 2004. First published December 17, 2003; doi:10.1152/jn.00900.2003
0022-3077/04 $5.00
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Equalization of Synaptic Efficacy by Activity- and Timing-Dependent Synaptic Plasticity

Clifton C. Rumsey and L. F. Abbott

Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110

Submitted 15 September 2003; accepted in final form 11 December 2003

In many neurons, synapses increase in strength as a function of distance from the soma in a manner that appears to compensate for dendritic attenuation. This phenomenon requires a cooperative interaction between local factors that control synaptic strength, such as receptor density and vesicle release probability, and global factors that affect synaptic efficacy, such as attenuation and boosting by active membrane conductances. Anti-spiketiming-dependent plasticity, in combination with nonassociative synaptic potentiation, can accomplish this feat even though it acts locally and independently at individual synapses. Analytic computations and computer simulations show that this combination of synaptic plasticity mechanisms equalizes the efficacy of synapses over an extended dendritic cable by adjusting local synaptic strengths to compensate for global attenuation.

Address reprint requests and other correspondence to: C. Rumsey (E-mail: rumsey{at}brandeis.edu).




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