JN Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 91: 2723-2733, 2004; doi:10.1152/jn.00249.2003
0022-3077/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borras, M. C.
Right arrow Articles by Borsook, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borras, M. C.
Right arrow Articles by Borsook, D.

FMRI Measurement of CNS Responses to Naloxone Infusion and Subsequent Mild Noxious Thermal Stimuli in Healthy Volunteers

M. C. Borras*, L. Becerra*, A. Ploghaus, J. M. Gostic, A. DaSilva, R. G. Gonzalez and D. Borsook

Center for Functional Pain Neuroimaging and Therapy Research, Athinoula A. Martinos Center for Biomedical Imaging, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02129

Submitted 17 March 2003; accepted in final form 2 December 2003

The aims of this study were to assess the effects of a µ-opioid antagonist, naloxone, on endogenous opioid systems and to evaluate the effect of naloxone on the CNS response to mild noxious heat. Doubled-blinded experiments were performed in a cross-over design in 10 healthy male volunteers. Functional magnetic resonance imaging (fMRI) data were collected before and during the infusion and also during thermal stimuli. Increased signal was observed in a number of cortical and subcortical brain regions for naloxone versus saline infusion. Cortical activation was induced in regions including cingulate, prefrontal cortex, and insula. Subcortical regions showing increased signal change included hippocampus and entorhinal cortex. A 46°C stimulus delivered to the back of the hand induced an overall increase in activation in a number of regions in the naloxone group that were not seen in the saline group (e.g., insula, orbitofrontal cortex, thalamus, and hippocampus). These results show that naloxone, even in the absence of psychophysical effects, produces activation in several brain regions that are known to have high levels of µ-opioid receptors and may be involved in endogenous analgesia. Our study is an example of how fMRI can measure subtle changes in brain activation induced by pharmacological agents without cognitive effects.

Present address and address for reprint requests and other correspondence: D. Borsook, Descartes Therapeutics, Inc., 790 Memorial Dr., Cambridge, MA 02139 (E-mail: dborsook{at}dtrx.cam.com).




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Z. Luo, M. Yu, S. D. Smith, M. Kritzer, C. Du, Y. Ma, N. D. Volkow, P. S. Glass, and H. Benveniste
The Effect of Intravenous Lidocaine on Brain Activation During Non-Noxious and Acute Noxious Stimulation of the Forepaw: A Functional Magnetic Resonance Imaging Study in the Rat
Anesth. Analg., January 1, 2009; 108(1): 334 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
D. J. Scott, C. S. Stohler, C. M. Egnatuk, H. Wang, R. A. Koeppe, and J.-K. Zubieta
Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses
Arch Gen Psychiatry, February 1, 2008; 65(2): 220 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
S. E. Kennedy, R. A. Koeppe, E. A. Young, and J.-K. Zubieta
Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women.
Arch Gen Psychiatry, November 1, 2006; 63(11): 1199 - 1208.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Becerra, S. Morris, S. Bazes, R. Gostic, S. Sherman, J. Gostic, G. Pendse, E. Moulton, S. Scrivani, D. Keith, et al.
Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli.
J. Neurosci., October 18, 2006; 26(42): 10646 - 10657.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. Becerra, K. Harter, R. G. Gonzalez, and D. Borsook
Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers.
Anesth. Analg., July 1, 2006; 103(1): 208 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. R. Smith, C. S. Stohler, T. E. Nichols, J. A. Bueller, R. A. Koeppe, and J.-K. Zubieta
Pronociceptive and Antinociceptive Effects of Estradiol through Endogenous Opioid Neurotransmission in Women
J. Neurosci., May 24, 2006; 26(21): 5777 - 5785.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.