HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 91/6/2782    most recent 01267.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Tamura, H. Articles by Fujita, I. Search for Related Content PubMed PubMed Citation Articles by Tamura, H. Articles by Fujita, I.

Presumed Inhibitory Neurons in the Macaque Inferior Temporal Cortex: Visual Response Properties and Functional Interactions With Adjacent Neurons

¹Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka, 560–8531; ²National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, 305–8566; and ³Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Toyonaka, Osaka, 560–8531, Japan

Submitted 29 December 2003; accepted in final form 2 January 2004

Neurons in area TE of the monkey inferior temporal cortex respond selectively to images of particular objects or their characteristic visual features. The mechanism of generation of the stimulus selectivity, however, is largely unknown. This study addresses the role of inhibitory TE neurons in this process by examining their visual response properties and interactions with adjacent target neurons. We applied cross-correlation analysis to spike trains simultaneously recorded from pairs of adjacent neurons in anesthetized macaques. Neurons whose activity preceded a decrease in activity from their partner were presumed to be inhibitory neurons. Excitatory neurons were also identified as the source neuron of excitatory linkage as evidenced by a sharp peak displaced from the 0-ms bin in cross-correlograms. Most inhibitory neurons responded to a variety of visual stimuli in our stimulus set, which consisted of several dozen geometrical figures and photographs of objects, with a clear stimulus preference. On average, 10% of the stimuli increased firing rates of the inhibitory neurons. Both excitatory and inhibitory neurons exhibited a similar degree of stimulus selectivity. Although inhibitory neurons occasionally shared the most preferred stimuli with their target neurons, overall stimulus preferences were less similar between adjacent neurons with inhibitory linkages than adjacent neurons with common inputs and/or excitatory linkages. These results suggest that inhibitory neurons in area TE are activated selectively and exert stimulus-specific inhibition on adjacent neurons, contributing to shaping of stimulus selectivity of TE neurons.

This article has been cited by other articles:

				B. Anderson, R. E.B. Mruczek, K. Kawasaki, and D. Sheinberg Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe Cereb Cortex, February 21, 2008; (2008) bhn015v1. [Abstract] [Full Text] [PDF]

				D. Zoccolan, M. Kouh, T. Poggio, and J. J. DiCarlo Trade-Off between Object Selectivity and Tolerance in Monkey Inferotemporal Cortex J. Neurosci., November 7, 2007; 27(45): 12292 - 12307. [Abstract] [Full Text] [PDF]

				T. Hirabayashi and Y. Miyashita Dynamically Modulated Spike Correlation in Monkey Inferior Temporal Cortex Depending on the Feature Configuration within a Whole Object J. Neurosci., November 2, 2005; 25(44): 10299 - 10307. [Abstract] [Full Text] [PDF]

				E. Curti, G. Mongillo, G. La Camera, and D. J. Amit Mean Field and Capacity in Realistic Networks of Spiking Neurons Storing Sparsely Coded Random Memories Neural Comput., December 1, 2004; 16(12): 2597 - 2637. [Abstract] [Full Text] [PDF]