Recent studies have reported the presence of single neurons with strong responses to visual inputs in the human medial temporal lobe. Here we demonstrate how repeated stimulus presentation - photos of celebrities and familiar individuals, landmark buildings, animals and objects - modulates the firing rate of these cells: a consistent decrease in the neural activity was registered as images were repeatedly shown during experimental sessions. The effect of novel stimuli was not the same for all medial temporal lobe structures, expressing differences among hippocampus, entorhinal cortex, amygdala and parahippocampal cortex. These findings are consistent with the view that MTL neurons link visual percepts to declarative memory.