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J Neurophysiol 92: 545-552, 2004; doi:10.1152/jn.00927.2003
0022-3077/04 $5.00
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Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Jeremy B. Bergsman1,2, Pietro De Camilli2 and David A. McCormick1

1Department of Neurobiology and 2Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8001

Submitted 24 September 2003; accepted in final form 12 February 2004

The calyx of Held is a giant nerve terminal that forms a synapse directly onto the principal cells of the medial nucleus of the trapezoid body (MNTB) in the mammalian auditory brain stem. This central synapse, which is involved in sound localization, has become widely used for studying synaptic transmission. Anatomical studies of this nucleus have indicated that each principal cell is innervated by only one calyx. Here we use previously established electrophysiological criteria of excitatory postsynaptic current amplitude, kinetics, and transmitter type, as well as other characteristics commonly reported for this synapse, to examine the input properties of principal neurons. Our findings indicate that some principal cells receive more than one strong excitatory input. These inputs meet previously established electrophysiological criteria for identification as calyceal nerve terminals. Implications for the execution and analysis of experiments to avoid errors due to such multiple inputs are discussed.

Address for reprint requests and other correspondence: J. Bergsman, Department of Neurobiology, P.O. Box 208001, New Haven, CT 06520-8001 (E-mail: jeremy{at}bergsman.org.)




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