| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH; 2Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom; and 3Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-3008
Submitted 9 February 2004; accepted in final form 22 March 2004
The responses of single subthalamic nucleus (STN) neurons to cortical activation are complex and depend on the relative activation of several neuronal circuits, making theoretical extrapolation of single neuron responses to the population level difficult. To understand better the degree of synchrony imposed on STN neurons and associated neuronal networks by cortical activation, we recorded the responses of single units, pairs of neighboring neurons, and local field potentials (LFPs) in STN to discrete electrical stimulation of the cortex in anesthetized rats. Stimulation of ipsilateral frontal cortex, but not temporal cortex, generated synchronized "multiphasic" responses in neighboring units in rostral STN, usually consisting of a brief, short-latency excitation, a brief inhibition, a second excitation, and a long-duration inhibition. Evoked LFPs in STN consistently mirrored unit responses; brief, negative deflections in the LFP coincided with excitations and brief, positive deflections with inhibitions. This characteristic LFP was dissimilar to potentials evoked in cortex and structures surrounding STN and was resistant to fluctuations in forebrain activity. The short-latency excitation and associated LFP deflection exhibited the highest fidelity to low-intensity cortical stimuli. Unit response failures, which mostly occurred in caudal STN, were not associated with LFPs typical of rostral STN. These data suggest that local populations of STN neurons can be synchronized by both direct and indirect cortical inputs. Synchronized ensemble activity is dependent on topography and input intensity. Finally, the stereotypical, multiphasic profile of the evoked LFP indicates that it might be useful for locating the STN in clinical as well as nonclinical settings.
This article has been cited by other articles:
|
|
 |
|
  N. Mallet, A. Pogosyan, A. Sharott, J. Csicsvari, J. P. Bolam, P. Brown, and P. J. Magill Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex J. Neurosci., April 30, 2008; 28(18): 4795 - 4806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Humphries, R. D. Stewart, and K. N. Gurney A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia J. Neurosci., December 13, 2006; 26(50): 12921 - 12942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weinberger, N. Mahant, W. D. Hutchison, A. M. Lozano, E. Moro, M. Hodaie, A. E. Lang, and J. O. Dostrovsky Beta Oscillatory Activity in the Subthalamic Nucleus and Its Relation to Dopaminergic Response in Parkinson's Disease J Neurophysiol, December 1, 2006; 96(6): 3248 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Meissner, A. Leblois, A. Benazzouz, and T. Boraud Reply to: Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm Subthalamic high-frequency stimulation drives subthalamic oscillatory activity at stimulation frequency while firing rate is reduced Brain, December 1, 2006; 129(12): e60 - e60. [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Magill, A. Sharott, J. P. Bolam, and P. Brown Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat J. Physiol., August 1, 2006; 574(3): 929 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Magill, A. Pogosyan, A. Sharott, J. Csicsvari, J. P. Bolam, and P. Brown Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo. J. Neurosci., June 7, 2006; 26(23): 6318 - 6329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marceglia, G. Foffani, A. M. Bianchi, G. Baselli, F. Tamma, M. Egidi, and A. Priori Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease J. Physiol., March 15, 2006; 571(3): 579 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Kass and I. M. Mintz Silent plateau potentials, rhythmic bursts, and pacemaker firing: Three patterns of activity that coexist in quadristable subthalamic neurons PNAS, January 3, 2006; 103(1): 183 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fogelson, D. Williams, M. Tijssen, G. van Bruggen, H. Speelman, and P. Brown Different Functional Loops between Cerebral Cortex and the Subthalmic Area in Parkinson's Disease Cereb Cortex, January 1, 2006; 16(1): 64 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Foffani, A. M Bianchi, G Baselli, and A Priori Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus J. Physiol., October 15, 2005; 568(2): 699 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Hallworth and M. D. Bevan Globus Pallidus Neurons Dynamically Regulate the Activity Pattern of Subthalamic Nucleus Neurons through the Frequency-Dependent Activation of Postsynaptic GABAA and GABAB Receptors J. Neurosci., July 6, 2005; 25(27): 6304 - 6315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharott, P. J Magill, J. P. Bolam, and P. Brown Directional analysis of coherent oscillatory field potentials in the cerebral cortex and basal ganglia of the rat J. Physiol., February 1, 2005; 562(3): 951 - 963. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
