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J Neurophysiol 92: 1312-1319, 2004; doi:10.1152/jn.00140.2004
0022-3077/04 $5.00
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Odorant Responses of Dual Polarity Are Mediated by cAMP in Mouse Olfactory Sensory Neurons

Rona Delay1 and Diego Restrepo2

1Department of Biology, University of Vermont, Burlington, Vermont 05405; and 2Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262

Submitted 10 February 2004; accepted in final form 5 May 2004

Some olfactory sensory neurons (OSNs) respond to odors with hyperpolarization. Although transduction for excitatory responses is mediated by opening of a cyclic nucleotide-gated (CNG) channel, there is controversy on the mechanism underlying inhibitory responses. We find that mouse OSNs respond to odorants by either depolarizing or hyperpolarizing responses in loose-patch measurements. In the perforated-patch configuration, OSNs not only responded with a current consistent with CNG channel-mediated excitation but also displayed enhancement of outward currents, consistent with inhibitory responses. Increasing cAMP levels pharmacologically elicited excitatory or inhibitory responses in different OSNs. In addition, OSNs from mice defective for the CNGA2 subunit of the CNG channel displayed neither excitatory nor inhibitory responses. Thus CNG channels mediate inhibitory olfactory responses.

Address for reprint requests and other correspondence: R. Delay, 104 Marsh Life Science, Biology Dept., University of Vermont, Burlington, VT 05405 (E-mail: rona.delay{at}uvm.edu).




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