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Theta Rhythmic Stimulation of Stratum Lacunosum-Moleculare in Rat Hippocampus Contributes to Associative LTP at a Phase Offset in Stratum Radiatum

Department of Psychology Center for Memory and Brain, Program in Neuroscience and Center for BioDynamics, Boston University, Boston, Massachusetts 02215

Submitted 29 August 2003; accepted in final form 2 May 2004

Computational modeling demonstrates that encoding and context-dependent retrieval of memories in region CA1 of the hippocampus will be most effective when the phase of strongest entorhinal input (to stratum lacunosum-moleculare) is offset from the phase of maximal induction of long-term potentiation at Schaffer collateral synapses (in s. radiatum). This would allow entorhinal input to play a role in both retrieval and encoding without engaging long-term potentiation (LTP) during retrieval. Experiments in brain slice preparations of the hippocampal formation tested the relationship between rhythmic input to s. lacunosum-moleculare and the time of maximal LTP induction at Schaffer collateral synapses in s. radiatum. Analysis of the data demonstrates a statistically significant difference in the induction of LTP for different time intervals between the end of each four-pulse train in s. lacunosum-moleculare and the single pulse s. radiatum stimulation. The time of maximal LTP induction was found to be 30 ms after the end of lacunosum-moleculare stimulation, consistent with the requirements of the model.

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