| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neurobiology, State University of New York, Stony Brook, New York 11794-5230
Submitted 30 March 2004; accepted in final form 10 May 2004
We used a juvenile mouse thalamocortical slice preparation with whole cell recording to investigate synaptic properties of corticothalamic inputs from somatosensory cortex to the ventral posterior medial and posterior medial nuclei (98 cells). We compared these data to those obtained from activating retinal and cortical inputs to the lateral geniculate nucleus (8 cells), the former representing a prototypical driver input and the latter, a typical modulator. Retinogeniculate activation evoked large, all-or-none excitatory postsynaptic potentials (EPSPs) that showed paired-pulse depression antagonized by N-methyl-D-aspartate (NMDA) and AMPA receptor blockers but with no sign of a metabotropic glutamate receptor (mGluR) component. Corticogeniculate activation evoked small, graded EPSPs showing paired-pulse facilitation, and the EPSPs showed both NMDA and AMPA receptor component plus an mGluR1 component. In the somatosensory thalamic relays, cortical stimulation elicited glutamatergic EPSPs in all thalamic cells, and these EPSPs fell into two groups. One, elicited from cortical layer 6 to cells of both nuclei, involved small, graded EPSPs with paired-pulse facilitation, and most also showed an mGluR1 component. The other, elicited from layer 5 to cells only of the posterior medial nucleus, involved large, all-or-none EPSPs with paired-pulse depression, and none showed an mGluR component. By analogy with results from the lateral geniculate nucleus, we conclude that the input from layer 6 to both nuclei acts as a modulator but that the layer 5 input to the posterior medial nucleus serves as a driver. Our data extend a common organizing principle from first-order nuclei to higher-order thalamic relays and further implicate the latter in corticocortical communication.
This article has been cited by other articles:
|
|
 |
|
  D. A. Llano and S. M. Sherman Differences in Intrinsic Properties and Local Network Connectivity of Identified Layer 5 and Layer 6 Adult Mouse Auditory Corticothalamic Neurons Support a Dual Corticothalamic Projection Hypothesis Cereb Cortex, December 1, 2009; 19(12): 2810 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Chomsung, H. Wei, J. D. Day-Brown, H. M. Petry, and M. E. Bickford Synaptic Organization of Connections between the Temporal Cortex and Pulvinar Nucleus of the Tree Shrew Cereb Cortex, October 1, 2009; (2009) bhp162v4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Lee and S. M. Sherman Glutamatergic Inhibition in Sensory Neocortex Cereb Cortex, October 1, 2009; 19(10): 2281 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Petrof and S. M. Sherman Synaptic Properties of the Mammillary and Cortical Afferents to the Anterodorsal Thalamic Nucleus in the Mouse J. Neurosci., June 17, 2009; 29(24): 7815 - 7819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Lam and S. M. Sherman Functional Organization of the Somatosensory Cortical Layer 6 Feedback to the Thalamus Cereb Cortex, May 15, 2009; (2009) bhp077v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wanaverbecq, A. L. Bodor, H. Bokor, A. Slezia, A. Luthi, and L. Acsady Contrasting the Functional Properties of GABAergic Axon Terminals with Single and Multiple Synapses in the Thalamus J. Neurosci., November 12, 2008; 28(46): 11848 - 11861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Groh, C. P. J. de Kock, V. C. Wimmer, B. Sakmann, and T. Kuner Driver or Coincidence Detector: Modal Switch of a Corticothalamic Giant Synapse Controlled by Spontaneous Activity and Short-Term Depression J. Neurosci., September 24, 2008; 28(39): 9652 - 9663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Lee and S. M. Sherman Synaptic Properties of Thalamic and Intracortical Inputs to Layer 4 of the First- and Higher-Order Cortical Areas in the Auditory and Somatosensory Systems J Neurophysiol, July 1, 2008; 100(1): 317 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Hooks and C. Chen Vision Triggers an Experience-Dependent Sensitive Period at the Retinogeniculate Synapse J. Neurosci., April 30, 2008; 28(18): 4807 - 4817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Landisman and B. W. Connors VPM and PoM Nuclei of the Rat Somatosensory Thalamus: Intrinsic Neuronal Properties and Corticothalamic Feedback Cereb Cortex, December 1, 2007; 17(12): 2853 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Lam and S. M. Sherman Different Topography of the Reticulothalmic Inputs to First- and Higher-Order Somatosensory Thalamic Relays Revealed Using Photostimulation J Neurophysiol, November 1, 2007; 98(5): 2903 - 2909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Smith, E. L. Bartlett, and A. Kowalkowski Cortical and Collicular Inputs to Cells in the Rat Paralaminar Thalamic Nuclei Adjacent to the Medial Geniculate Body J Neurophysiol, August 1, 2007; 98(2): 681 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H.P. Kole, A. U. Brauer, and G. J. Stuart Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model J. Physiol., January 15, 2007; 578(2): 507 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Lam, C. S. Nelson, and S. M. Sherman Mapping of the Functional Interconnections Between Thalamic Reticular Neurons Using Photostimulation J Neurophysiol, November 1, 2006; 96(5): 2593 - 2600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Arsenault and Z.-w. Zhang Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse J. Physiol., May 15, 2006; 573(1): 121 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Sirota, H. A. Swadlow, and I. N. Beloozerova Three Channels of Corticothalamic Communication during Locomotion J. Neurosci., June 22, 2005; 25(25): 5915 - 5925. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
