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J Neurophysiol 92: 2610-2614, 2004. First published June 16, 2004; doi:10.1152/jn.00466.2004
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Protective Effect of Ifenprodil Against Spreading Depression in the Mouse Entorhinal Cortex

Leonardo Coutinho Faria1,2 and Istvan Mody2

1Departamento de Neurologia e Neurocirurgia, UNIFESP–Escola Paulista de Medicina, São Paulo, SP 04023-900, Brazil; and 2Departments of Neurology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095–1769

Submitted 5 May 2004; accepted in final form 9 June 2004

In the brain, spreading depression (SD) is characterized by a large extracellular DC shift, a massive failure of ion homeostasis and a transient cessation of neuronal function. Clinically, SD is believed to be involved in various neurological disorders including migraine and cerebrovascular diseases. The propagation of cortical SD requires the release of glutamate, and N-methyl-D-aspartate (NMDA) receptors play a crucial role in this process. Here, we have isolated the NMDA receptor-mediated component of extracellularly recorded field excitatory postsynaptic potentials (fEPSPs) in layers 2–3 of the entorhinal cortex of murine brain slices. In the absence of GABAA and AMPA receptor-mediated synaptic transmission, stimulation of layer 6 afferents every 15–90 s elicited spontaneous SD on average within 18.5 min after the start of the stimulation. In the presence of ifenprodil, an NR2B receptor subunit-selective NMDA receptor antagonist, the occurrence of SD was nearly abolished. Our results are consistent with an important role of NR2B subunits in triggering SD in the entorhinal cortex.

Address for reprint requests and other correspondence: I. Mody, Dept. of Neurology, RNRC 3-155, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 (E-mail: mody{at}ucla.edu).




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[Abstract] [Full Text] [PDF]


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