HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Hayashida, Y. Articles by Ishida, A. T. Search for Related Content PubMed PubMed Citation Articles by Hayashida, Y. Articles by Ishida, A. T.

REPORT

Dopamine Receptor Activation Can Reduce Voltage-Gated Na⁺ Current by Modulating Both Entry Into and Recovery From Inactivation

Section of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616

Submitted 19 May 2004; accepted in final form 22 June 2004

We tested whether dopamine receptor activation modulates the voltage-gated Na⁺ current of goldfish retinal ganglion cells, using a fast voltage-clamp amplifier, perforated-patch whole cell mode, and a physiological extracellular Na⁺ concentration. As found in other cells, activators of D1-type dopamine receptors and of protein kinase A reduced the amplitude of current activated by depolarizations from resting potential without altering the current kinetics or activation range. However, D1-type dopamine receptor activation also accelerated the rate of entry into inactivation during subthreshold depolarizations and slowed the rate of recovery from inactivation after single, brief depolarizations. Our results provide the first evidence in any preparation that D1-type receptor activation can produce both of these latter effects.

This article has been cited by other articles:

				D. K. Mojumder, D. M. Sherry, and L. J. Frishman Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram J. Physiol., May 15, 2008; 586(10): 2551 - 2580. [Abstract] [Full Text] [PDF]

				S. C. Lee and A. T. Ishida Ih Without Kir in Adult Rat Retinal Ganglion Cells J Neurophysiol, May 1, 2007; 97(5): 3790 - 3799. [Abstract] [Full Text] [PDF]

				T. Ichinose and P. D. Lukasiewicz Ambient Light Regulates Sodium Channel Activity to Dynamically Control Retinal Signaling J. Neurosci., April 25, 2007; 27(17): 4756 - 4764. [Abstract] [Full Text] [PDF]

				J. A. Rosenkranz and D. Johnston Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex. J. Neurosci., March 22, 2006; 26(12): 3229 - 3244. [Abstract] [Full Text] [PDF]

				J. F. Cheer, M. L. A. V. Heien, P. A. Garris, R. M. Carelli, and R. M. Wightman Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation PNAS, December 27, 2005; 102(52): 19150 - 19155. [Abstract] [Full Text] [PDF]

				L. Huang, H. Maaswinkel, and L. Li Olfactoretinal centrifugal input modulates zebrafish retinal ganglion cell activity: a possible role for dopamine-mediated Ca2+ signalling pathways J. Physiol., December 15, 2005; 569(3): 939 - 948. [Abstract] [Full Text] [PDF]

				N. K. Dhingra, M. A. Freed, and R. G. Smith Voltage-Gated Sodium Channels Improve Contrast Sensitivity of a Retinal Ganglion Cell J. Neurosci., August 31, 2005; 25(35): 8097 - 8103. [Abstract] [Full Text] [PDF]

				T. Tabata, S. Haruki, H. Nakayama, and M. Kano GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells J. Physiol., March 1, 2005; 563(2): 443 - 457. [Abstract] [Full Text] [PDF]