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J Neurophysiol 92: 3148-3152, 2004. First published June 16, 2004; doi:10.1152/jn.00356.2004
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REPORT

A Developmental Switch in Acute Sensitization of Small Dorsal Root Ganglion (DRG) Neurons to Capsaicin or Noxious Heating by NGF

Weiguo Zhu1, Sam M. Galoyan2, Jeffrey C. Petruska2, Gerry S. Oxford1 and Lorne M. Mendell2

1Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202; and 2Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794-5230

Submitted 6 April 2004; accepted in final form 13 June 2004

Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4–P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin- and NGF-induced sensitization.

Address for reprint requests and other correspondence: G. S. Oxford, Stark Neurosciences Research Inst., Indiana Univ. School of Medicine, 950 W. Walnut St., Rm. 402 Research II Bldg., Indianapolis, IN 46202 (E-mail: goxford{at}iupui.edu).




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