HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Appendices All Versions of this Article: 93/2/1069    most recent 00504.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Shouval, H. Z. Articles by Kalantzis, G. Search for Related Content PubMed PubMed Citation Articles by Shouval, H. Z. Articles by Kalantzis, G.

Stochastic Properties of Synaptic Transmission Affect the Shape of Spike Time–Dependent Plasticity Curves

¹Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston; and ²Department of Biomedical Engineering, University of Texas, Austin, Texas

Submitted 12 May 2004; accepted in final form 21 September 2004

Theoretical studies have shown that calcium influx through N-methyl-D-aspartate (NMDA) receptors is a sufficient signal to account for various induction protocols of bidirectional synaptic plasticity, including spike time–dependent plasticity (STDP). The STDP curves obtained by these different models exhibits a form of spike time–dependent long-term depression that occurs when a presynaptic spike precedes the postsynaptic spike (pre-post LTD). We have previously proposed that this novel form of LTD can serve as an experimental test for the validity of these models. These calcium based theoretical models assumed deterministic calcium dynamics that reflect average properties of synaptic calcium currents. In this paper, we show that taking into account the stochastic properties of synaptic transmission significantly alters the form of STDP curves and may significantly reduce the magnitude of pre-post LTD.

This article has been cited by other articles:

				X. Yu, H. Z. Shouval, and J. J. Knierim A Biophysical Model of Synaptic Plasticity and Metaplasticity Can Account for the Dynamics of the Backward Shift of Hippocampal Place Fields J Neurophysiol, August 1, 2008; 100(2): 983 - 992. [Abstract] [Full Text] [PDF]

				H. Urakubo, M. Honda, R. C. Froemke, and S. Kuroda Requirement of an Allosteric Kinetics of NMDA Receptors for Spike Timing-Dependent Plasticity J. Neurosci., March 26, 2008; 28(13): 3310 - 3323. [Abstract] [Full Text] [PDF]

				R. C. Gerkin, P.-M. Lau, D. W. Nauen, Y. T. Wang, and G.-Q. Bi Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity J Neurophysiol, April 1, 2007; 97(4): 2851 - 2862. [Abstract] [Full Text] [PDF]

				Y. Cai, J. P. Gavornik, L. N. Cooper, L. C. Yeung, and H. Z. Shouval Effect of Stochastic Synaptic and Dendritic Dynamics on Synaptic Plasticity in Visual Cortex and Hippocampus J Neurophysiol, January 1, 2007; 97(1): 375 - 386. [Abstract] [Full Text] [PDF]

				T. Nevian and B. Sakmann Spine Ca2+ Signaling in Spike-Timing-Dependent Plasticity J. Neurosci., October 25, 2006; 26(43): 11001 - 11013. [Abstract] [Full Text] [PDF]

				V. A. Bender, K. J. Bender, D. J. Brasier, and D. E. Feldman Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J. Neurosci., April 19, 2006; 26(16): 4166 - 4177. [Abstract] [Full Text] [PDF]

				R. C. Froemke, I. A. Tsay, M. Raad, J. D. Long, and Y. Dan Contribution of Individual Spikes in Burst-Induced Long-Term Synaptic Modification J Neurophysiol, March 1, 2006; 95(3): 1620 - 1629. [Abstract] [Full Text] [PDF]

				J. E. Rubin, R. C. Gerkin, G.-Q. Bi, and C. C. Chow Calcium Time Course as a Signal for Spike-Timing-Dependent Plasticity J Neurophysiol, May 1, 2005; 93(5): 2600 - 2613. [Abstract] [Full Text] [PDF]