| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | SEARCH RESULT |
|
|
|
|||||||
|
|||||||||
1Department of Biomedical Engineering and 3Department of Mathematics, Center for BioDynamics, Center for Memory and Brain, Boston University, Boston, Massachusetts; and 2Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin
Submitted 20 September 2004; accepted in final form 31 October 2004
Understanding the mechanistic bases of neuronal synchronization is a current challenge in quantitative neuroscience. We studied this problem in two putative cellular pacemakers of the mammalian hippocampal theta rhythm: glutamatergic stellate cells (SCs) of the medial entorhinal cortex and GABAergic oriens-lacunosum-moleculare (O-LM) interneurons of hippocampal region CA1. We used two experimental methods. First, we measured changes in spike timing induced by artificial synaptic inputs applied to individual neurons. We then measured responses of free-running hybrid neuronal networks, consisting of biological neurons coupled (via dynamic clamp) to biological or virtual counterparts. Results from the single-cell experiments predicted network behaviors well and are compatible with previous model-based predictions of how specific membrane mechanisms give rise to empirically measured synchronization behavior. Both cell types phase lock stably when connected via homogeneous excitatory-excitatory (E-E) or inhibitory-inhibitory (I-I) connections. Phase-locked firing is consistently synchronous for either cell type with E-E connections and nearly anti-synchronous with I-I connections. With heterogeneous connections (e.g., excitatory-inhibitory, as might be expected if members of a given population had heterogeneous connections involving intermediate interneurons), networks often settled into phase locking that was either stable or unstable, depending on the order of firing of the two cells in the hybrid network. Our results imply that excitatory SCs, but not inhibitory O-LM interneurons, are capable of synchronizing in phase via monosynaptic mutual connections of the biologically appropriate polarity. Results are largely independent of synaptic strength and synaptic kinetics, implying that our conclusions are robust and largely unaffected by synaptic plasticity.
This article has been cited by other articles:
|
|
 |
|
  W. C. Stacey, M. T. Lazarewicz, and B. Litt Synaptic Noise and Physiological Coupling Generate High-Frequency Oscillations in a Hippocampal Computational Model J Neurophysiol, October 1, 2009; 102(4): 2342 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Sieling, C. C. Canavier, and A. A. Prinz Predictions of Phase-Locking in Excitatory Hybrid Networks: Excitation Does Not Promote Phase-Locking in Pattern-Generating Networks as Reliably as Inhibition J Neurophysiol, July 1, 2009; 102(1): 69 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, C. C. Canavier, and R. J. Butera Functional Phase Response Curves: A Method for Understanding Synchronization of Adapting Neurons J Neurophysiol, July 1, 2009; 102(1): 387 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Achuthan and C. C. Canavier Phase-Resetting Curves Determine Synchronization, Phase Locking, and Clustering in Networks of Neural Oscillators J. Neurosci., April 22, 2009; 29(16): 5218 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Fernandez and J. A. White Artificial Synaptic Conductances Reduce Subthreshold Oscillations and Periodic Firing in Stellate Cells of the Entorhinal Cortex J. Neurosci., April 2, 2008; 28(14): 3790 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Leibold, A. Gundlfinger, R. Schmidt, K. Thurley, D. Schmitz, and R. Kempter Temporal compression mediated by short-term synaptic plasticity PNAS, March 18, 2008; 105(11): 4417 - 4422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Silver, K. Boahen, S. Grillner, N. Kopell, and K. L. Olsen Neurotech for Neuroscience: Unifying Concepts, Organizing Principles, and Emerging Tools J. Neurosci., October 31, 2007; 27(44): 11807 - 11819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Z. Kiss, C. G. Rusin, H. Kori, and J. L. Hudson Engineering Complex Dynamical Structures: Sequential Patterns and Desynchronization Science, June 29, 2007; 316(5833): 1886 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Radman, Y. Su, J. H. An, L. C. Parra, and M. Bikson Spike Timing Amplifies the Effect of Electric Fields on Neurons: Implications for Endogenous Field Effects J. Neurosci., March 14, 2007; 27(11): 3030 - 3036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Mancilla, T. J. Lewis, D. J. Pinto, J. Rinzel, and B. W. Connors Synchronization of Electrically Coupled Pairs of Inhibitory Interneurons in Neocortex J. Neurosci., February 21, 2007; 27(8): 2058 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Colicos and N. I. Syed Neuronal networks and synaptic plasticity: understanding complex system dynamics by interfacing neurons with silicon technologies J. Exp. Biol., June 15, 2006; 209(12): 2312 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Goaillard and E. Marder Dynamic Clamp Analyses of Cardiac, Endocrine, and Neural Function Physiology, June 1, 2006; 21(3): 197 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-D. Zhou, C. D. Acker, T. I. Netoff, K. Sen, and J. A. White Increasing Ca2+ transients by broadening postsynaptic action potentials enhances timing-dependent synaptic depression PNAS, December 27, 2005; 102(52): 19121 - 19125. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | SEARCH RESULT |
| Visit Other APS Journals Online |
