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J Neurophysiol 93: 1372-1380, 2005. First published November 3, 2004; doi:10.1152/jn.00990.2004
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Pharmacological Properties and Functional Role of a TRP-Related Ion Channel in Lobster Olfactory Receptor Neurons

Yuriy V. Bobkov1 and Barry W. Ache1,2

1Whitney Laboratory for Marine Bioscience, 2Departments of Zoology and Neuroscience, Center for Smell and Taste, and McKnight Brain Institute, University of Florida, Gainesville, Florida

Submitted 21 September 2004; accepted in final form 26 October 2004

Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na+-gated nonselective cation channel. The Na+-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365 ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.

Address for reprint requests and other correspondence: Y. V. Bobkov, Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St. Augustine, FL 32080-8610 (E-mail: bobkov{at}whitney.ufl.edu)




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