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J Neurophysiol 94: 2-4, 2005; doi:10.1152/classicessays.00031.2005
0022-3077/05 $8.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Aristides Leão’s discovery of cortical spreading depression

This essay looks at the historical significance of three APS classic papers that are freely available online:

Leão AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390, 1944 (http://jn.physiology.org/cgi/reprint/7/6/359).

Leão AAP. Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 391–396, 1944 (http://jn.physiology.org/cgi/reprint/7/6/391).

Leão AAP. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 10: 409–414, 1947 (http://jn.physiology.org/cgi/reprint/10/6/409).