HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 94/1/567    most recent 00896.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Shinomoto, S. Articles by Fujita, I. Search for Related Content PubMed PubMed Citation Articles by Shinomoto, S. Articles by Fujita, I.

Regional and Laminar Differences in In Vivo Firing Patterns of Primate Cortical Neurons

¹Graduate School of Science, Kyoto University, Kyoto; ²Graduate School of Frontier Biosciences, Osaka University, Osaka; and ³Hitachi, Totsuka, Yokohama, Japan

Submitted 30 August 2004; accepted in final form 7 March 2005

The firing rates of cortical neurons change in time; yet, some aspects of their in vivo firing characteristics remain unchanged and are specific to individual neurons. A recent study has shown that neurons in the monkey medial motor areas can be grouped into 2 firing types, "likely random" and "quasi-regular," according to a measure of local variation of interspike intervals. In the present study, we extended this analysis to area TE of the inferior temporal cortex and addressed whether this classification applies generally to different cortical areas and whether different types of neurons show different laminar distribution. We found that area TE did consist of 2 groups of neurons with different firing characteristics, one similar to the "likely random" type in the medial motor cortical areas, and the other exhibiting a "clumpy-bursty" firing pattern unique to TE. The quasi-regular type was rarely observed in area TE. The likely random firing type of neuron was more frequently found in layers V–VI than in layers II–III, whereas the opposite was true for the clumpy-bursty firing type. These results show that neocortical areas consist of heterogeneous neurons that differ from one area to another in their basic firing characteristics. Moreover, we show that spike trains obtained from a single cortical neuron can provide a clue that helps to identify its layer localization.

This article has been cited by other articles:

				K. Miura, Y. Tsubo, M. Okada, and T. Fukai Balanced Excitatory and Inhibitory Inputs to Cortical Neurons Decouple Firing Irregularity from Rate Modulations J. Neurosci., December 12, 2007; 27(50): 13802 - 13812. [Abstract] [Full Text] [PDF]

				H. Shimazaki and S. Shinomoto A Method for Selecting the Bin Size of a Time Histogram Neural Comput., June 1, 2007; 19(6): 1503 - 1527. [Abstract] [Full Text] [PDF]

				D. Durstewitz and T. Gabriel Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons Cereb Cortex, April 1, 2007; 17(4): 894 - 908. [Abstract] [Full Text] [PDF]

				G. La Camera, A. Rauch, D. Thurbon, H.-R. Luscher, W. Senn, and S. Fusi Multiple Time Scales of Temporal Response in Pyramidal and Fast Spiking Cortical Neurons J Neurophysiol, December 1, 2006; 96(6): 3448 - 3464. [Abstract] [Full Text] [PDF]

				K. Miura, M. Okada, and S.-i. Amari Estimating Spiking Irregularities Under Changing Environments. Neural Comput., October 1, 2006; 18(10): 2359 - 2386. [Abstract] [Full Text] [PDF]