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Remapping the Remembered Target Location for Anti-Saccades in Human Posterior Parietal Cortex

¹Nijmegen Institute for Cognition and Information, ²FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands; ³Canadian Institutes of Health Research Group on Action and Perception, ⁴Imaging Research Labs, Robarts Research Institute, London, Ontario; and ⁵Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada

Submitted 23 December 2004; accepted in final form 22 March 2005

We used functional magnetic resonance imaging (fMRI) to investigate the role of the human posterior parietal cortex (PPC) in anti-saccades. To do so, we exploited the laterality of a subregion of the PPC for remembered target location. Using an event-related design, we tracked fMRI signal changes in this region while subjects remembered the location of a flashed target, then were instructed to plan either an anti- or pro-saccade to that location, and finally were instructed to execute the movement. At first, the region responded preferentially to the memory of a target location presented in the contralateral visual field. However, when an anti-cue specified a saccadic response into the opposite visual field, we observed a dynamic shift in cortical activity from one hemisphere to the other. This shows that this region within the human posterior parietal cortex codes the target location for an upcoming saccade, rather than the location of the remembered visual stimulus in an anti-saccade task.

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