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J Neurophysiol 94: 813-820, 2005. First published February 23, 2005; doi:10.1152/jn.01200.2004
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Distinct Roles for Lateral and Medial Anterior Prefrontal Cortex in Contextual Recollection

Jon S. Simons1, Sam J. Gilbert1, Adrian M. Owen2, Paul C. Fletcher3 and Paul W. Burgess1

1Institute of Cognitive Neuroscience and Department of Psychology, University College London; 2Medical Research Council Cognition and Brain Sciences Unit, Cambridge; and 3Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

Submitted 22 November 2004; accepted in final form 21 February 2005

A key feature of human recollection is the ability to remember details of the context in which events were experienced, as well as details of the events themselves. Previous studies have implicated a number of regions of prefrontal cortex in contextual recollection, but the role of anterior prefrontal cortex has so far resisted detailed characterization. We used event-related functional MRI (fMRI) to contrast recollection of two forms of contextual information: 1) decisions one had previously made about stimuli (task memory) and 2) which of two temporally distinct lists those stimuli had been presented in (list memory). In addition, a retrieval cue manipulation permitted evaluation of the stage of the retrieval process in which the activated regions might be involved. The results indicated that anterior prefrontal cortex responded significantly more during recollection of task than list context details. Furthermore, activation profiles for lateral and medial aspects of anterior prefrontal cortex suggested differing roles in recollection. Lateral regions seem to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification).

Address for reprint requests and other correspondence: J. Simons, Inst. of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UK (E-mail: jon.simons{at}ucl.ac.uk)




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