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This Article Full Text Full Text (PDF) All Versions of this Article: 94/2/1413    most recent 00217.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Otmakhova, N. A. Articles by Lisman, J. E. Search for Related Content PubMed PubMed Citation Articles by Otmakhova, N. A. Articles by Lisman, J. E.

Inhibition of Perforant Path Input to the CA1 Region by Serotonin and Noradrenaline

Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts

Submitted 1 March 2005; accepted in final form 8 May 2005

Bath-applied monoamines—dopamine (DA), serotonin (5-HT), and noradrenaline (NE)—strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input. The effect of DA action on PP field excitatory postsynaptic potential (fEPSP) has been characterized in detail, but relatively little is known about the NE and 5-HT effects. Here we show that the maximal inhibition of the PP fEPSP by NE is 55%, whereas 5-HT inhibition is weaker (35%). The half-maximal inhibitory concentration of both 5-HT and NE is 1 µM. Neither NE nor 5-HT affected paired-pulse facilitation, suggesting that the effect is not presynaptic. This is in contrast to DA, which does have a presynaptic effect. The NE effect was blocked by ₂ antagonists, whereas the ₁ antagonist corynanthine and -antagonist propranolol were ineffective. The effect of 5-HT was mimicked by the agonist, 5-carboxamidotryptamine maleate (5-CT), and not affected by adrenergic and dopaminergic antagonists. To determine the 5-HT receptors involved, we tested a number of 5-HT antagonists, but none produced a complete suppression of the 5-HT effect. Of these, only the 5-HT₇ and 5-HT₂ antagonists produced weak but significant inhibition of 5-HT effect. We conclude that NE inhibits the PP fEPSP through postsynaptic action on ₂-adrenoceptors and that 5-HT₇, 5-HT₂, and some other receptor may be involved in 5-HT action in PP.

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