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This Article Full Text Full Text (PDF) All Versions of this Article: 94/2/1509    most recent 00957.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Rotstein, H. G. Articles by Kopell, N. Search for Related Content PubMed PubMed Citation Articles by Rotstein, H. G. Articles by Kopell, N.

Slow and Fast Inhibition and an H-Current Interact to Create a Theta Rhythm in a Model of CA1 Interneuron Network

Horacio G. Rotstein¹, Dmitri D. Pervouchine¹, Corey D. Acker², Martin J. Gillies³, John A. White², Eberhardt H. Buhl, Miles A. Whittington³ and Nancy Kopell¹

¹Department of Mathematics and Statistics and ²Department of Biomedical Engineering and Center for Biodynamics, Boston University, Boston, Massachusetts; and ³School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom

Submitted 14 September 2004; accepted in final form 27 March 2005

The oriens-lacunosum moleculare (O-LM) subtype of interneuron is a key component in the formation of the theta rhythm (8–12 Hz) in the hippocampus. It is known that the CA1 region of the hippocampus can produce theta rhythms in vitro with all ionotropic excitation blocked, but the mechanisms by which this rhythmicity happens were previously unknown. Here we present a model suggesting that individual O-LM cells, by themselves, are capable of producing a single-cell theta-frequency firing, but coupled O-LM cells are not capable of producing a coherent population theta. By including in the model fast-spiking (FS) interneurons, which give rise to IPSPs that decay faster than those of the O-LM cells, coherent theta rhythms are produced. The inhibition to O-LM cells from the FS cells synchronizes the O-LM cells, but only when the FS cells themselves fire at a theta frequency. Reciprocal connections from the O-LM cells to the FS cells serve to parse the FS cell firing into theta bursts, which can then synchronize the O-LM cells. A component of the model O-LM cell critical to the synchronization mechanism is the hyperpolarization-activated h-current. The model can robustly reproduce relative phases of theta frequency activity in O-LM and FS cells.

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