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This Article Full Text Full Text (PDF) All Versions of this Article: 94/3/1849    most recent 01275.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Lu, H. Articles by Bower, J. M. Search for Related Content PubMed PubMed Citation Articles by Lu, H. Articles by Bower, J. M.

Correlations Between Purkinje Cell Single-Unit Activity and Simultaneously Recorded Field Potentials in the Immediately Underlying Granule Cell Layer

¹Division of Biology, California Institute of Technology, Pasadena, California; ²Departments of Mechanical and Biomedical Engineering, Northwestern University, Evanston, Illinois; and ³Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas

Submitted 13 December 2004; accepted in final form 29 May 2005

Evidence from both anatomical and physiological studies suggests that the ascending segment of the granule cell axon provides a large, driving input to overlying Purkinje cells. In the current experiments, we used dual recording electrodes to simultaneously record spike activity of Purkinje cells and multiunit field potential activity in the directly underlying granule cell layer. These dual recordings were performed both during periods of spontaneous ("background") firing and also after peripheral tactile stimulation. The results demonstrate that in the large majority of cases, there is a strong positive correlation between spontaneous Purkinje cell simple spikes and spontaneous activity in the immediately underlying granule cell layer. The strength of this correlation was dependent on both the firing rate of the Purkinje cell as well as on the rate of granule cell layer multiunit activity. In addition, for any given pair of recordings, the correlation seen during spontaneous activity accurately predicted the magnitude and time course of responses evoked by peripheral tactile stimulation. These results provide additional evidence that the synapses associated with the ascending segment of the granule cell axon have a substantial influence on Purkinje cell output. This relationship is considered in the context of our ongoing reevaluation of the physiological relationship between cerebellar granule and Purkinje cells.

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