HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 94/4/2713    most recent 00024.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Chen, D. Articles by Fetz, E. E. Search for Related Content PubMed PubMed Citation Articles by Chen, D. Articles by Fetz, E. E.

Characteristic Membrane Potential Trajectories in Primate Sensorimotor Cortex Neurons Recorded In Vivo

¹Systems and Cognitive Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland; and ²Department of Physiology and Biophysics, Washington National Primate Research Center, University of Washington School of Medicine, Seattle, Washington

Submitted 10 January 2005; accepted in final form 26 June 2005

We examined the membrane potentials and firing properties of motor cortical neurons recorded intracellularly in awake, behaving primates. Three classes of neuron were distinguished by 1) the width of their spikes, 2) the shape of the afterhyperpolarization (AHP), and 3) the distribution of interspike intervals. Type I neurons had wide spikes, exhibited scoop-shaped AHPs, and fired irregularly. Type II neurons had narrower spikes, showed brief postspike afterdepolarizations before the AHP, and sometimes fired high-frequency doublets. Type III neurons had the narrowest spikes, showed a distinct post-AHP depolarization, or "rebound AHP" (rAHP), lasting nearly 30 ms, and tended to fire at 25–35 Hz. The evidence suggests that an intrinsic rAHP may confer on these neurons a tendency to fire at a preferred frequency governed by the duration of the rAHP and may contribute to a "pacemaking" role in generating cortical oscillations.

This article has been cited by other articles:

				S. R. Williams and S. E. Atkinson Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits J. Physiol., December 15, 2007; 585(3): 759 - 777. [Abstract] [Full Text] [PDF]

				W. K. Mitchell, M. R. Baker, and S. N. Baker Muscle responses to transcranial stimulation in man depend on background oscillatory activity J. Physiol., September 1, 2007; 583(2): 567 - 579. [Abstract] [Full Text] [PDF]

				B. Haider, A. Duque, A. R. Hasenstaub, Y. Yu, and D. A. McCormick Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo J Neurophysiol, June 1, 2007; 97(6): 4186 - 4202. [Abstract] [Full Text] [PDF]

				C. L. Witham and S. N. Baker Network oscillations and intrinsic spiking rhythmicity do not covary in monkey sensorimotor areas J. Physiol., May 1, 2007; 580(3): 801 - 814. [Abstract] [Full Text] [PDF]

				W. Truccolo and J. P. Donoghue Nonparametric Modeling of Neural Point Processes via Stochastic Gradient Boosting Regression. Neural Comput., March 1, 2007; 19(3): 672 - 705. [Abstract] [Full Text] [PDF]

				R. M. Davies, G. L. Gerstein, and S. N. Baker Measurement of Time-Dependent Changes in the Irregularity of Neural Spiking J Neurophysiol, August 1, 2006; 96(2): 906 - 918. [Abstract] [Full Text] [PDF]

				B. Haider, A. Duque, A. R. Hasenstaub, and D. A. McCormick Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. J. Neurosci., April 26, 2006; 26(17): 4535 - 4545. [Abstract] [Full Text] [PDF]