HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 94/4/2738    most recent 00362.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Turner, J. G. Articles by Caspary, D. M. Search for Related Content PubMed PubMed Citation Articles by Turner, J. G. Articles by Caspary, D. M.

Affects of Aging on Receptive Fields in Rat Primary Auditory Cortex Layer V Neurons

¹Departments of Pharmacology and ²Surgery, Southern Illinois University School of Medicine, Springfield, Illinois

Submitted 8 April 2005; accepted in final form 27 June 2005

Advanced age is commonly associated with progressive cochlear pathology and central auditory deficits, collectively known as presbycusis. The present study examined central correlates of presbycusis by measuring response properties of primary auditory cortex (AI) layer V neurons in the Fischer Brown Norway rat model. Layer V neurons represent the major output of AI to other cortical and subcortical regions (primarily the inferior colliculus). In vivo single-unit extracellular recordings were obtained from 114 neurons in aged animals (29–33 mo) and compared with 105 layer V neurons in young-adult rats (4–6 mo). Three consecutive repetitions of a pure-tone receptive field map were run for each neuron. Age was associated with fewer neurons exhibiting classic V/U-shaped receptive fields and a greater percentage of neurons with more Complex receptive fields. Receptive fields from neurons in aged rats were also less reliable on successive repetitions of the same stimulus set. Aging was also associated with less firing during the stimulus in V/U-shaped receptive field neurons and more firing during the stimulus in Complex neurons, which were generally associated with inhibited firing in young controls. Finally, neurons in aged rats with Complex receptive fields were more easily driven by current pulses delivered to the soma. Collectively, these findings provide support for the notion that age is associated with diminished signal-to-noise coding by AI layer V neurons and are consistent with other research suggesting that GABAergic neurotransmission in AI may be compromised by aging.

This article has been cited by other articles:

				D. M. Caspary, L. Ling, J. G. Turner, and L. F. Hughes Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system J. Exp. Biol., June 1, 2008; 211(11): 1781 - 1791. [Abstract] [Full Text] [PDF]