| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
REPORT
1Vollum Institute, Oregon Health and Science University; and 2Biology Department, Reed College, Portland, Oregon
Submitted 17 June 2005; accepted in final form 14 July 2005
Neurogenesis in the dentate gyrus begins before birth but then continues into adulthood. Consequently, many newborn granule cells must integrate into a preexisting hippocampal network. Little is known about the timing of this process or the characteristics of the first established synapses. We used mice that transiently express enhanced green fluorescent protein in newborn granule cells to examine their synaptic input. Although newborn granule cells had functional glutamate receptors, evoked and spontaneous synaptic currents were exclusively GABAergic with immature characteristics including slow rise and decay phases and depolarized reversal potentials. Synaptic currents in newborn granule cells were relatively insensitive to the GABAA receptor modulator zolpidem compared with neighboring mature granule cells. Consistent with the kinetics and pharmacology, newborn granule cells isolated by fluorescent cell sorting lacked the 
1 GABAA receptor subunit. Our results indicate that newborn granule cells initially receive only GABAergic synapses even in the adult.
This article has been cited by other articles:
|
|
 |
|
  C. W. Habela, N. J. Ernest, A. F. Swindall, and H. Sontheimer Chloride Accumulation Drives Volume Dynamics Underlying Cell Proliferation and Migration J Neurophysiol, February 1, 2009; 101(2): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Luo, J. Lathia, M. Mughal, and M. P. Mattson SDF1{alpha}/CXCR4 Signaling, via ERKs and the Transcription Factor Egr1, Induces Expression of a 67-kDa Form of Glutamic Acid Decarboxylase in Embryonic Hippocampal Neurons J. Biol. Chem., September 5, 2008; 283(36): 24789 - 24800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ge, K. A. Sailor, G.-l. Ming, and H. Song Synaptic integration and plasticity of new neurons in the adult hippocampus J. Physiol., August 15, 2008; 586(16): 3759 - 3765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Markwardt and L. Overstreet-Wadiche GABAergic signalling to adult-generated neurons J. Physiol., August 15, 2008; 586(16): 3745 - 3749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kolodziej, S. Schulz, A. Guyon, D.-F. Wu, M. Pfeiffer, V. Odemis, V. Hollt, and R. Stumm Tonic Activation of CXC Chemokine Receptor 4 in Immature Granule Cells Supports Neurogenesis in the Adult Dentate Gyrus J. Neurosci., April 23, 2008; 28(17): 4488 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A Riquelme, E. Drapeau, and F. Doetsch Brain micro-ecologies: neural stem cell niches in the adult mammalian brain Phil Trans R Soc B, January 12, 2008; 363(1489): 123 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Pathak, F. Weissinger, M. Terunuma, G. C. Carlson, F.-C. Hsu, S. J. Moss, and D. A. Coulter Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy J. Neurosci., December 19, 2007; 27(51): 14012 - 14022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations Physiol Rev, October 1, 2007; 87(4): 1215 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jessberger, C. Zhao, N. Toni, G. D. Clemenson Jr, Y. Li, and F. H. Gage Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling J. Neurosci., August 29, 2007; 27(35): 9400 - 9407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cancedda, H. Fiumelli, K. Chen, and M.-m. Poo Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo J. Neurosci., May 9, 2007; 27(19): 5224 - 5235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Earnheart, C. Schweizer, F. Crestani, T. Iwasato, S. Itohara, H. Mohler, and B. Luscher GABAergic Control of Adult Hippocampal Neurogenesis in Relation to Behavior Indicative of Trait Anxiety and Depression States J. Neurosci., April 4, 2007; 27(14): 3845 - 3854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Magby, C. Bi, Z.-Y. Chen, F. S. Lee, and M. R. Plummer Single-Cell Characterization of Retrograde Signaling by Brain-Derived Neurotrophic Factor J. Neurosci., December 27, 2006; 26(52): 13531 - 13536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. C. Piatti, M. S. Esposito, and A. F. Schinder The Timing of Neuronal Development in Adult Hippocampal Neurogenesis Neuroscientist, December 1, 2006; 12(6): 463 - 468. [Abstract] [PDF]
|
|
|
|
 |
|
 M. D. Saxe, F. Battaglia, J.-W. Wang, G. Malleret, D. J. David, J. E. Monckton, A. D. R. Garcia, M. V. Sofroniew, E. R. Kandel, L. Santarelli, et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus PNAS, November 14, 2006; 103(46): 17501 - 17506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Overstreet-Wadiche, D. A. Bromberg, A. L. Bensen, and G. L. Westbrook Seizures Accelerate Functional Integration of Adult-Generated Granule Cells J. Neurosci., April 12, 2006; 26(15): 4095 - 4103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Overstreet-Wadiche, A. L. Bensen, and G. L. Westbrook Delayed development of adult-generated granule cells in dentate gyrus. J. Neurosci., February 22, 2006; 26(8): 2326 - 2334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vicini GABA Comes First to Newly Generated Neurons. Focus on "GABAergic Signal to Newborn Neurons in Dentate Gyrus" J Neurophysiol, December 1, 2005; 94(6): 3661 - 3661. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
