HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 95/3/1309    most recent 00901.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Kuwada, S. Articles by Ostapoff, E.-M. Search for Related Content PubMed PubMed Citation Articles by Kuwada, S. Articles by Ostapoff, E.-M.

TRANSLATIONAL PHYSIOLOGY

Sensitivity to Interaural Time Differences in the Dorsal Nucleus of the Lateral Lemniscus of the Unanesthetized Rabbit: Comparison With Other Structures

¹Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut; ²Department of Otolaryngology, University of North Carolina, Chapel Hill, North Carolina; ³Department of Anatomy and Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Mississippi; and ⁴Connecticut State Department of Public Health, Hartford, Connecticut

Submitted 29 August 2005; accepted in final form 6 December 2005

Interaural time differences, a cue for azimuthal sound location, are first encoded in the superior olivary complex (SOC), and this information is then conveyed to the dorsal nucleus of the lateral lemniscus (DNLL) and inferior colliculus (IC). The DNLL provides a strong inhibitory input to the IC and may serve to transform the coding of interaural time differences (ITDs) in the IC. Consistent with the projections from the SOC, the DNLL and IC had similar distributions of peak- and trough-type neurons, characteristic delays, and best ITDs. The ITD tuning widths of DNLL neurons were intermediate between those of the SOC and IC. Further sharpening is seen in the auditory thalamus, indicating that sharpening mechanisms are not restricted to the midbrain. The proportion of neurons that phase-locked to the tones delivered to each ear progressively decreased from the SOC to the auditory thalamus. The degree of phase-locking for a large majority of DNLL neurons was too weak to support their involvement in processing monaural inputs to generate a sensitivity to ITDs. The response rates of DNLL neurons were on average 60% greater than in the IC or SOC, indicating that the inhibitory input provided to the IC by the DNLL is robust.

This article has been cited by other articles:

				I. Siveke, S. D. Ewert, B. Grothe, and L. Wiegrebe Psychophysical and Physiological Evidence for Fast Binaural Processing J. Neurosci., February 27, 2008; 28(9): 2043 - 2052. [Abstract] [Full Text] [PDF]

				M. Mc Laughlin, B. Van de Sande, M. van der Heijden, and P. X. Joris Comparison of Bandwidths in the Inferior Colliculus and the Auditory Nerve. I. Measurement Using a Spectrally Manipulated Stimulus J Neurophysiol, November 1, 2007; 98(5): 2566 - 2579. [Abstract] [Full Text] [PDF]

				K. A. Davis, O. Lomakin, and M. J. Pesavento Response Properties of Single Units in the Dorsal Nucleus of the Lateral Lemniscus of Decerebrate Cats J Neurophysiol, September 1, 2007; 98(3): 1475 - 1488. [Abstract] [Full Text] [PDF]