JN AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 95: 1620-1629, 2006. First published November 30, 2005; doi:10.1152/jn.00910.2005
0022-3077/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/3/1620    most recent
00910.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Froemke, R. C.
Right arrow Articles by Dan, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Froemke, R. C.
Right arrow Articles by Dan, Y.

Contribution of Individual Spikes in Burst-Induced Long-Term Synaptic Modification

Robert C. Froemke1,2, Ishan A. Tsay3, Mohamad Raad1,2, John D. Long1,2 and Yang Dan1,2,3

1Division of Neurobiology, Department of Molecular and Cell Biology; 2Helen Wills Neuroscience Institute; 3Graduate Group in Biophysics, University of California, Berkeley, California

Submitted 31 August 2005; accepted in final form 26 November 2005

Long-term synaptic modification depends on the relative timing of individual pre- and postsynaptic spikes, but the rules governing the effects of multispike bursts remain to be fully understood. In particular, some studies suggest that the spike timing dependence of synaptic modification breaks down with high-frequency bursts. In this study, we characterized the effects of pre- and postsynaptic bursts on long-term modification of layer 2/3 synapses in visual cortical slices from young rats. We found that, while pairing-induced synaptic modification depends on the burst frequency, this dependence can be explained in terms of the timing of individual pre- and postsynaptic spikes. Later spikes in each burst are less effective in synaptic modification, but spike efficacy is regulated differently in pre- and postsynaptic bursts. Presynaptically, spike efficacy is progressively weakened, in parallel with short-term synaptic depression. Postsynaptically, spike efficacy is suppressed to a lesser extent, and it depends on postsynaptic potassium channel activation. Such timing-dependent interaction among multiple spikes can account for synaptic modifications induced by a variety of spike trains, including the frequency-dependent transition from depression to potentiation induced by a postsynaptic burst preceding a presynaptic burst.

Address for reprint requests and other correspondence: Y. Dan (E-mail: ydan{at}berkeley.edu)




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Gidon and I. Segev
Spike-Timing-Dependent Synaptic Plasticity and Synaptic Democracy in Dendrites
J Neurophysiol, June 1, 2009; 101(6): 3226 - 3234.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. T. R. Isaac, K. A. Buchanan, R. U. Muller, and J. R. Mellor
Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro
J. Neurosci., May 27, 2009; 29(21): 6840 - 6850.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Urakubo, M. Honda, R. C. Froemke, and S. Kuroda
Requirement of an Allosteric Kinetics of NMDA Receptors for Spike Timing-Dependent Plasticity
J. Neurosci., March 26, 2008; 28(13): 3310 - 3323.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Farries and A. L. Fairhall
Reinforcement Learning With Modulated Spike Timing Dependent Synaptic Plasticity
J Neurophysiol, December 1, 2007; 98(6): 3648 - 3665.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. A. Buchanan and J. R. Mellor
The development of synaptic plasticity induction rules and the requirement for postsynaptic spikes in rat hippocampal CA1 pyramidal neurones
J. Physiol., December 1, 2007; 585(2): 429 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Jacob, D. J. Brasier, I. Erchova, D. Feldman, and D. E. Shulz
Spike Timing-Dependent Synaptic Depression in the In Vivo Barrel Cortex of the Rat
J. Neurosci., February 7, 2007; 27(6): 1271 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Cai, J. P. Gavornik, L. N. Cooper, L. C. Yeung, and H. Z. Shouval
Effect of Stochastic Synaptic and Dendritic Dynamics on Synaptic Plasticity in Visual Cortex and Hippocampus
J Neurophysiol, January 1, 2007; 97(1): 375 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. S. Haas, T. Nowotny, and H.D.I. Abarbanel
Spike-Timing-Dependent Plasticity of Inhibitory Synapses in the Entorhinal Cortex
J Neurophysiol, December 1, 2006; 96(6): 3305 - 3313.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-P. Pfister and W. Gerstner
Triplets of spikes in a model of spike timing-dependent plasticity.
J. Neurosci., September 20, 2006; 26(38): 9673 - 9682.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.