JN Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 95: 1992-1995, 2006. First published December 21, 2005; doi:10.1152/jn.01042.2005
0022-3077/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/3/1992    most recent
01042.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cadetti, L.
Right arrow Articles by Thoreson, W. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cadetti, L.
Right arrow Articles by Thoreson, W. B.

REPORT

Feedback Effects of Horizontal Cell Membrane Potential on Cone Calcium Currents Studied With Simultaneous Recordings

Lucia Cadetti1 and Wallace B. Thoreson1,2

1Departments of Ophthalmology and Visual Science and 2Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska

Submitted 3 October 2005; accepted in final form 15 December 2005

Horizontal cell (HC) to cone feedback helps establish the center-surround arrangement of visual receptive fields. It has been shown that HC activity influences cone synaptic output by altering the amplitude and voltage dependence of the calcium current (ICa) in cones. In this study, we obtained voltage-clamp recordings simultaneously from cones and HCs to directly control the membrane potential of HCs and thereby measure the influence of HC membrane potential changes on ICa in adjacent cones. Directly hyperpolarizing voltage clamped HCs produced a negative activation shift and increased the amplitude of ICa in cones. Both of these effects were abolished by enhancing extracellular pH buffering capacity with HEPES. In contrast, addition of the gap junction blocker, carbenoxolone, did not significantly alter the shifts or amplitude changes in cone ICa produced by changes in HC membrane potential. These results support the hypothesis that changes in the HC membrane potential alter the voltage dependence and amplitude of cone ICa by altering extracellular pH levels at the synapse.

Address for reprint requests and other correspondence: W. B. Thoreson, Dept. of Ophthalmology, Univ. of Nebraska Medical Center, Durham Research Center, Omaha, NE 68198-5840 (E-mail: wbthores{at}unmc.edu)




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. D. Crook, C. M. Davenport, B. B. Peterson, O. S. Packer, P. B. Detwiler, and D. M. Dacey
Parallel ON and OFF Cone Bipolar Inputs Establish Spatially Coextensive Receptive Field Structure of Blue-Yellow Ganglion Cells in Primate Retina
J. Neurosci., July 1, 2009; 29(26): 8372 - 8387.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Palacios-Prado, S. Sonntag, V. A. Skeberdis, K. Willecke, and F. F. Bukauskas
Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina
J. Physiol., July 1, 2009; 587(13): 3251 - 3269.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Babai and W. B. Thoreson
Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina
J. Physiol., May 1, 2009; 587(10): 2353 - 2364.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. B. Thoreson, N. Babai, and T. M. Bartoletti
Feedback from Horizontal Cells to Rod Photoreceptors in Vertebrate Retina
J. Neurosci., May 28, 2008; 28(22): 5691 - 5695.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. M. Davenport, P. B. Detwiler, and D. M. Dacey
Effects of pH Buffering on Horizontal and Ganglion Cell Light Responses in Primate Retina: Evidence for the Proton Hypothesis of Surround Formation
J. Neurosci., January 9, 2008; 28(2): 456 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. L. Becker, K. F. Webb, C. Thrasivoulou, C.-C. Lin, R. Nadershahi, N. Tsakiri, and J. E. Cook
Multiphoton imaging of chick retinal development in relation to gap junctional communication
J. Physiol., December 15, 2007; 585(3): 711 - 719.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Jouhou, K. Yamamoto, A. Homma, M. Hara, A. Kaneko, and M. Yamada
Depolarization of isolated horizontal cells of fish acidifies their immediate surrounding by activating V-ATPase
J. Physiol., December 1, 2007; 585(2): 401 - 412.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
M. A. Kreitzer, L. P. Collis, A. J.A. Molina, P. J.S. Smith, and R. P. Malchow
Modulation of Extracellular Proton Fluxes from Retinal Horizontal Cells of the Catfish by Depolarization and Glutamate
J. Gen. Physiol., July 30, 2007; 130(2): 169 - 182.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. G. Jonz and S. Barnes
Proton modulation of ion channels in isolated horizontal cells of the goldfish retina
J. Physiol., June 1, 2007; 581(2): 529 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Sheng, S.-Y. Choi, A. Dharia, J. Li, P. Sterling, and R. H. Kramer
Synaptic Ca2+ in Darkness Is Lower in Rods than Cones, Causing Slower Tonic Release of Vesicles
J. Neurosci., May 9, 2007; 27(19): 5033 - 5042.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.