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J Neurophysiol 95: 2553-2559, 2006. First published January 4, 2006; doi:10.1152/jn.00842.2005
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Effects on Neural Function of Repleting Vitamin E–Deficient Rats With {alpha}-Tocopherol

Samantha M. Hayton1,2, Tony Kriss2, Angie Wade3 and David P. R. Muller1

1Biochemistry, Endocrinology and Metabolism Unit, 2Visual Science Unit, and 3Centre for Paediatic Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom

Submitted 10 August 2005; accepted in final form 22 December 2005

A severe and chronic deficiency of vitamin E ({alpha}-tocopherol) is associated with a characteristic neurological syndrome with typical "clinical," neuropathological, and electrophysiological abnormalities in both humans and experimental animals. Repletion of vitamin E–deficient human subjects with {alpha}-tocopherol typically halts the progression of the neural signs and symptoms, and in some cases, can result in objective improvement. Electrophysiological parameters provide an objective measure of neural and visual function and improvement of some of these measures has been reported after repletion with vitamin E in humans. In this longitudinal study, the effects of repleting rats with a diet containing 36 mg/kg all-rac-{alpha}-tocopheryl acetate for 20 wk after they had been receiving a vitamin E–deficient diet for 38 wk was studied. We report significant improvements in growth and a number of electrophysiological parameters of both neural and visual function after repletion. These results confirm the validity of the vitamin E–deficient rat as a model of vitamin E deficiency in humans.

Address for reprint requests and other correspondence: D.P.R. Muller, Biochemistry, Endocrinology and Metabolism Unit, Inst. of Child Health, 30 Guilford St., London WC1N 1EH, UK (E-mail: D.Muller{at}ich.ucl.ac.uk)






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