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J Neurophysiol 95: 2947-2950, 2006. First published February 15, 2006; doi:10.1152/jn.01328.2005
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Stimulus for Rapid Ocular Dominance Plasticity in Visual Cortex

Cynthia D. Rittenhouse1, Beth A. Siegler1, Courtney A. Voelker1, Harel Z. Shouval2, Michael A. Paradiso1 and Mark F. Bear1,3

1Department of Neuroscience and 2Department of Physics, Brown University, Providence, Rhode Island; and 3Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts

Submitted 16 December 2005; accepted in final form 11 February 2006

Although it has been known for decades that monocular deprivation shifts ocular dominance in kitten striate cortex, uncertainty persists about the adequate stimulus for deprivation-induced losses of cortical responsiveness. In the current study we compared the effects of 2 days of lid closure and 2 days of monocular blur using an overcorrecting contact lens. Our finding of comparable ocular dominance shifts in visual cortex indicates that deprived-eye response depression is not a result of reduced retinal illumination. The quality rather than the quantity of retinal illumination is the key factor for ocular dominance plasticity. These data have implications for both the mechanism and treatment of amblyopia.

Address for reprint requests and other correspondence: M. Bear, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Bldg. 46-3301, 77 Massachusetts Ave., Cambridge, MA 02139 (E-mail: mbear{at}mit.edu)




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