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Audio-Visual Multisensory Integration in Superior Parietal Lobule Revealed by Human Intracranial Recordings

¹The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S. Kline Institute for Psychiatric Research, Orangeburg; ²Department of Neurological Surgery and ³Department of Radiology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York; ⁴Dartmouth Functional Brain Imaging Center, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire; and ⁵Program in Cognitive Neuroscience, Department of Psychology, The City College of the City University of New York, New York, New York

Submitted 15 March 2006; accepted in final form 6 May 2006

Intracranial recordings from three human subjects provide the first direct electrophysiological evidence for audio-visual multisensory processing in the human superior parietal lobule (SPL). Auditory and visual sensory inputs project to the same highly localized region of the parietal cortex with auditory inputs arriving considerably earlier (30 ms) than visual inputs (75 ms). Multisensory integration processes in this region were assessed by comparing the response to simultaneous audio-visual stimulation with the algebraic sum of responses to the constituent auditory and visual unisensory stimulus conditions. Significant integration effects were seen with almost identical morphology across the three subjects, beginning between 120 and 160 ms. These results are discussed in the context of the role of SPL in supramodal spatial attention and sensory-motor transformations.

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