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This Article Full Text Full Text (PDF) All Versions of this Article: 96/5/2388    most recent 00442.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Batra, R. Search for Related Content PubMed PubMed Citation Articles by Batra, R.

Responses of Neurons in the Ventral Nucleus of the Lateral Lemniscus to Sinusoidally Amplitude Modulated Tones

Department of Anatomy and Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Mississippi

Submitted 26 April 2006; accepted in final form 28 July 2006

Fluctuations in the amplitude of a sound play an important role in our perception of pitch and acoustic space, but their neural analysis has not been fully elucidated. The ventral nucleus of the lateral lemniscus (VNLL) has been implicated in the processing of such temporal features of a sound. This study examines responses of neurons in the VNLL of unanesthetized rabbits to sinusoidally amplitude modulated tones, a type of stimulus that has often been used to investigate encoding of temporal information. Modulation transfer functions of responses were calculated in two ways: based on discharge rates (rMTFs) and on synchronization to the envelope (tMTFs). Among the variety of rMTFs, two types were readily identifiable: flat and band-pass. The responses of neurons exhibiting these types of rMTF differed in several ways. Neurons with flat rMTFs typically had moderate rates of spontaneous activity, sustained responses to short tone bursts, and low-pass or band-pass tMTFs. Neurons with band-pass rMTFs typically had low spontaneous activity, onset responses to short tone bursts, and flat tMTFs. The vast majority synchronized strongly to the modulation envelope. The best modulation frequencies of neurons with band-pass rMTFs extended from 14 to 283 Hz. The presence of neurons with band-pass rMTFs in the VNLL suggests that this nucleus plays a role in converting the temporal code for modulation frequency used in lower structures into a rate-based code for use higher in the auditory pathway. The substantial number of neurons with more complex modulation transfer functions indicates that the VNLL has other functions.