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Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep

Departments of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand

Submitted 7 September 2006; accepted in final form 30 October 2006

Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 ± 0.2°C to <34°C; mean ± SD), from 90 min to 70 h after the end of the insult, on postocclusion epileptiform activity. In the first 6 h after the end of occlusion, fetal electroencephalographic (EEG) activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery (r² = 0.65, P = 0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures, and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase but not of numbers of delayed seizures.

This article has been cited by other articles:

				L. Bennet, L. C. Booth, N. Ahmed-Nasef, J. M. Dean, J. Davidson, J. S. Quaedackers, and A. J. Gunn Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1280 - R1286. [Abstract] [Full Text] [PDF]