HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 97/5/3806    most recent 00101.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Fleming, R. L. Articles by Swartzwelder, H. S. Search for Related Content PubMed PubMed Citation Articles by Fleming, R. L. Articles by Swartzwelder, H. S.

REPORT

Magnitude and Ethanol Sensitivity of Tonic GABA_A Receptor-Mediated Inhibition in Dentate Gyrus Changes From Adolescence to Adulthood

¹Departments of Psychiatry and ²Pharmacology, Duke University Medical Center; and ³Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina

Submitted 30 January 2007; accepted in final form 18 March 2007

Ethanol consumption by adolescents is a public health problem of striking importance. Educational and clinical efforts to address this problem have been aided by recent neurobehavioral studies indicating that ethanol disrupts memory and memory-related brain functions more powerfully in adolescent animals than in adults. Still, the mechanisms underlying this developmental sensitivity remain unclear. GABA_A receptor (GABA_AR)-mediated neurotransmission in the hippocampal formation, particularly that which is driven by extrasynaptic GABA_ARs, is enhanced by pharmacologically relevant concentrations of ethanol, and may be, in part, responsible for the modulation of memory and memory-related circuit plasticity. Using hippocampal slices from adolescent and adult rats, we have shown that tonic current mediated by extrasynaptic GABA_ARs is larger in dentate gyrus granule cells from adult animals than in those from adolescents and that 30 mM ethanol enhances inhibitory tonic current more in cells from adolescent rats than in those from adults. It is possible that more powerful promotion of tonic GABA_AR-mediated inhibition by ethanol in the dentate gyrus of adolescent rats, compared with adults, contributes to the developmental differences that have previously been observed with respect to ethanol-induced memory impairment and reduction of synaptic plasticity.

This article has been cited by other articles:

				H. Yan, Q. Li, R. Fleming, R. D. Madison, W. A. Wilson, and H. S. Swartzwelder Developmental Sensitivity of Hippocampal Interneurons to Ethanol: Involvement of the Hyperpolarization-Activated Current, Ih J Neurophysiol, January 1, 2009; 101(1): 67 - 83. [Abstract] [Full Text] [PDF]

				D.-S. Choi, W. Wei, J. K. Deitchman, V. N. Kharazia, H. M. B. Lesscher, T. McMahon, D. Wang, Z.-H. Qi, W. Sieghart, C. Zhang, et al. Protein Kinase C{delta} Regulates Ethanol Intoxication and Enhancement of GABA-Stimulated Tonic Current J. Neurosci., November 12, 2008; 28(46): 11890 - 11899. [Abstract] [Full Text] [PDF]

				T. S. Otis Comments on "Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the {alpha}6 GABAA Receptor Subunit" J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 399 - 400. [Full Text] [PDF]

				C. F. Valenzuela, R. A. Radcliffe, P. Botta, and M. Mameli Response to Comment on "Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the {alpha}6 GABAA Receptor Subunit" J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 401 - 403. [Full Text] [PDF]

				P. Botta, M. Mameli, K. L. Floyd, R. A. Radcliffe, and C. F. Valenzuela Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the {alpha}6 GABAA Receptor Subunit J. Pharmacol. Exp. Ther., November 1, 2007; 323(2): 684 - 691. [Abstract] [Full Text] [PDF]