HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 98/4/1871    most recent 00593.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Montemurro, M. A. Articles by Petersen, R. S. Search for Related Content PubMed PubMed Citation Articles by Montemurro, M. A. Articles by Petersen, R. S.

Role of Precise Spike Timing in Coding of Dynamic Vibrissa Stimuli in Somatosensory Thalamus

¹Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom; and ²Instituto de Neurociencias de Alicante, Universidad Miguel Hernández–Consejo Superior de Investigaciones Cientificas, Alicante, Spain

Submitted 25 May 2007; accepted in final form 30 July 2007

Rats discriminate texture by whisking their vibrissae across the surfaces of objects. This process induces corresponding vibrissa vibrations, which must be accurately represented by neurons in the somatosensory pathway. In this study, we investigated the neural code for vibrissa motion in the ventroposterior medial (VPm) nucleus of the thalamus by single-unit recording. We found that neurons conveyed a great deal of information (up to 77.9 bits/s) about vibrissa dynamics. The key was precise spike timing, which typically varied by less than a millisecond from trial to trial. The neural code was sparse, the average spike being remarkably informative (5.8 bits/spike). This implies that as few as four VPm spikes, coding independent information, might reliably differentiate between 10⁶ textures. To probe the mechanism of information transmission, we compared the role of time-varying firing rate to that of temporally correlated spike patterns in two ways: 93.9% of the information encoded by a neuron could be accounted for by a hypothetical neuron with the same time-dependent firing rate but no correlations between spikes; moreover, 93.4% of the information in the spike trains could be decoded even if temporal correlations were ignored. Taken together, these results suggest that the essence of the VPm code for vibrissa motion is firing rate modulation on a submillisecond timescale. The significance of such a code may be that it enables a small number of neurons, firing only few spikes, to convey distinctions between very many different textures to the barrel cortex.

This article has been cited by other articles:

				M. R. Bale and R. S. Petersen Transformation in the Neural Code for Whisker Deflection Direction Along the Lemniscal Pathway J Neurophysiol, November 1, 2009; 102(5): 2771 - 2780. [Abstract] [Full Text] [PDF]

				S. R. Schultz, K. Kitamura, A. Post-Uiterweer, J. Krupic, and M. Hausser Spatial Pattern Coding of Sensory Information by Climbing Fiber-Evoked Calcium Signals in Networks of Neighboring Cerebellar Purkinje Cells J. Neurosci., June 24, 2009; 29(25): 8005 - 8015. [Abstract] [Full Text] [PDF]

				G. Foffani, M. L. Morales-Botello, and J. Aguilar Spike Timing, Spike Count, and Temporal Information for the Discrimination of Tactile Stimuli in the Rat Ventrobasal Complex J. Neurosci., May 6, 2009; 29(18): 5964 - 5973. [Abstract] [Full Text] [PDF]